Multitalented synthetic antimicrobial peptides and their antibacterial, antifungal and antiviral mechanisms

T Vanzolini, M Bruschi, AC Rinaldi, M Magnani… - International Journal of …, 2022 - mdpi.com
Despite the great strides in healthcare during the last century, some challenges still
remained unanswered. The development of multi-drug resistant bacteria, the alarming …

Vancomycin Resistance in Enterococcus and Staphylococcus aureus

G Li, MJ Walker, DMP De Oliveira - Microorganisms, 2022 - mdpi.com
Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common
commensals and major opportunistic human pathogens. In recent decades, these bacteria …

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

TF Dos Reis, PA De Castro, RW Bastos… - Nature …, 2023 - nature.com
Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal
drug resistance, novel strategies are urgently needed to combat life-threatening fungal …

Accelerating the discovery and design of antimicrobial peptides with artificial intelligence

MC Aguilera-Puga, NL Cancelarich, MM Marani… - … drug discovery and …, 2023 - Springer
Peptides modulate many processes of human physiology targeting ion channels, protein
receptors, or enzymes. They represent valuable starting points for the development of new …

[HTML][HTML] Antimicrobial peptides: Opportunities and challenges in overcoming resistance

C Bucataru, C Ciobanasu - Microbiological Research, 2024 - Elsevier
Antibiotic resistance represents a global health threat, challenging the efficacy of traditional
antimicrobial agents and necessitating innovative approaches to combat infectious …

Protective barriers provided by the epidermis

S de Szalay, PW Wertz - International Journal of Molecular Sciences, 2023 - mdpi.com
The skin is the largest organ of the body and consists of an epidermis, dermis and
subcutaneous adipose tissue. The skin surface area is often stated to be about 1.8 to 2 m2 …

Antimicrobial peptides and cell-penetrating peptides: non-antibiotic membrane-targeting strategies against bacterial infections

X Huang, G Li - Infection and Drug Resistance, 2023 - Taylor & Francis
The prevalence of antimicrobial resistance (AMR) has been rising quickly in recent years.
AMR has emerged as a significant obstacle to the treatment of infectious diseases, and …

Functional peptides for plant disease control

E Montesinos - Annual Review of Phytopathology, 2023 - annualreviews.org
Plant disease control requires novel approaches to mitigate the spread of and losses
caused by current, emerging, and re-emerging diseases and to adapt plant protection to …

Pyrgos[n]cages: Redefining antibacterial strategy against drug resistance

Y Zhang, M Luo, X Shi, A Li, W Zhou, Y Yin, H Wang… - Science …, 2024 - science.org
Amid rising antibiotic resistance, the quest for advanced antibacterial agents to surpass
microbial adaptation is paramount. This study introduces Pyrgos [n] cages (n= 1 to 4) …

Biodegradable polymers and polymer composites with antibacterial properties

A Smola-Dmochowska, K Lewicka, A Macyk… - International journal of …, 2023 - mdpi.com
Antibiotic resistance is one of the greatest threats to global health and food security today. It
becomes increasingly difficult to treat infectious disorders because antibiotics, even the …