In type 1 diabetes, insulin remains the mature therapeutic cornerstone; yet, the increasing
number of individuals developing type 1 diabetes (predominantly children and adolescents) …

Dendritic cells (DCs) dictate the outcomes of tissue-specific immune responses. In the
context of autoimmune diseases, DCs instruct T cells to respond to antigens (Ags), including …

Objectives We explored the effects of B-cell directed therapy in subjects at risk of developing
autoantibodypositive rheumatoid arthritis (RA), who never experienced inflammatory arthritis …

Background Type 1 diabetes is characterised by progressive loss of functional β-cell mass,
necessitating insulin treatment. We aimed to investigate the hypothesis that combining anti …

Type 1 diabetes is an autoimmune disease initiated by the invasion of pancreatic islets by
immune cells that selectively kill the β cells. We found that rodent and human T lymphocytes …

Susceptibility to multiple autoimmune diseases is associated with common gene
polymorphisms influencing IL-2 signaling and T reg function, making T reg-specific …

Mitochondria are principal metabolic organelles that are increasingly unveiled as immune
regulators. However, it is currently not known whether mitochondrial-encoded peptides …

Diabetes is the fastest growing chronic disease globally, with prevalence increasing at a
faster rate than heart disease and cancer. While the disease presents clinically as chronic …

Chronic inflammation is linked to diverse disease processes, but the intrinsic mechanisms
that determine cellular sensitivity to inflammation are incompletely understood. Here, we …

Type 1 and type 2 diabetes are distinct clinical entities primarily driven by autoimmunity and
metabolic dysfunction, respectively. However, there is a growing appreciation that they may …