Drug-induced liver injury (DILI) is an important clinical problem, which has received more
attention in recent decades. It can be induced by small chemical molecules, biological …

Drug-induced skin rashes are poorly understood idiosyncratic reactions, and current
methods cannot predict their occurrence. Most idiosyncratic drug reactions are thought to be …

Liver injury as a result of a sterile inflammation is closely linked to the activation of immune
cells, including macrophages, by damaged hepatocytes. This interaction between immune …

Introduction The mechanism of the immediate adverse drug reactions (ADRs) induced by
ShenMai injection (SMI) has not been completely elucidated. Within 30 minutes, the ears …

In a recent study, we reported that interleukin (IL)-4 had a protective role against
acetaminophen (APAP)-induced liver injury (AILI), although the mechanism of protection …

Background While the mechanisms underlying the development of drug‐induced liver injury
are not clear, there is evidence to suggest that tumor necrosis factor‐α (TNF‐α) plays an …

The main goal of this study was to evaluate tumor necrosis factor-alpha (TNF-α) gene
silencing in peritoneal macrophages upon activation with lipopolysaccharide (LPS), using …

Isoniazid (INH) and rifampicin (RIF) continue to be first line anti‑tuberculosis (TB) drugs.
However, the use of these drugs is associated with hepatotoxicity. Nuclear factor‑κB (NF‑κB) …

Drug complication is still considered as one of the most important causes of death and drug
in-compliance around the world. In this cross sectional study, 372 people living with HIV …