Abstract Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene) is a natural phenol that is present in
the skin of the grape, blueberry, raspberry, mulberry, and peanut. This substance is …

The mitogen-activated protein kinase (MAPK) pathway is essential for cellular proliferation,
growth, and survival. Constitutive activation of this pathway by BRAF mutations can cause …

Multidrug resistance (MDR) to anticancer drugs remains a serious obstacle to the success of
cancer chemotherapy. Resveratrol, a polyphenol, present in natural products exerts …

Abstract Development of the resistance is the major problem in cancer therapy. Docetaxel is
a taxol alkaloid that is frequently used in metastatic breast cancer. However, resistance often …

Chemotherapeutic agents are commonly used as neoadjuvant for breast cancer therapy.
However, there is evidence of treatment failure for most of patients due to acquired …

Abstract BRAF V600E is a constitutive BRAF (B-raf proto-oncogene, serine/threonine
kinase) mutation that accounts for more than 90% of BRAF mutations in melanoma …

The incidence of skin cancers, both nonmelanoma and melanoma, is increasing in the
United States. The ultraviolet radiation, mainly from sun, is considered the major cause for …

Melanoma is a malignant neoplasia that is highly resistant to chemotherapy and
radiotherapy and is associated with poor prognosis in advanced stage. Targeting melanoma …

Melanoma is the most fatal form of skin cancer. Current therapeutic approaches include
surgical resection, chemotherapy, targeted therapy and immunotherapy. However, these …

Background: Omipalisib has been found to affect the viability of cancer cells. However, its
effect on clonogenicity–a feature of cancer stem cells, is not clear. Cells isolated from …