The role of microglia heterogeneity in synaptic plasticity and brain disorders: Will sequencing shed light on the discovery of new therapeutic targets?
Y You, Z Chen, WW Hu - Pharmacology & Therapeutics, 2024 - Elsevier
Microglia play a crucial role in interacting with neuronal synapses and modulating synaptic
plasticity. This function is particularly significant during postnatal development, as microglia …
plasticity. This function is particularly significant during postnatal development, as microglia …
[HTML][HTML] Current perspectives on microglia-neuron communication in the central nervous system: Direct and indirect modes of interaction
Y Hu, W Tao - Journal of advanced research, 2024 - Elsevier
Background The incessant communication that takes place between microglia and neurons
is essential the development, maintenance, and pathogenesis of the central nervous system …
is essential the development, maintenance, and pathogenesis of the central nervous system …
Microglia activation in the presence of intact blood–brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric …
Introduction Inflammatory mediators are detected in the cerebrospinal fluid of systemic lupus
erythematosus patients with central nervous system involvement (NPSLE), yet the …
erythematosus patients with central nervous system involvement (NPSLE), yet the …
[HTML][HTML] Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer's disease-like mouse model
X Sun, X Yu, J Zhu, L Li, L Zhang, Y Huang… - … and Targeted Therapy, 2023 - nature.com
Passive immunotherapy is one of the most promising interventions for Alzheimer's disease
(AD). However, almost all immune-modulating strategies fail in clinical trials with unclear …
(AD). However, almost all immune-modulating strategies fail in clinical trials with unclear …
[HTML][HTML] Novel CSF biomarkers for diagnosis and integrated analysis of neuropsychiatric systemic lupus erythematosus: based on antibody profiling
J Ni, C Chen, S Wang, X Liu, L Tan, L Lu, Y Fan… - Arthritis Research & …, 2023 - Springer
Background Neuropsychiatric systemic lupus erythematosus (NPSLE), with various
morbidities and multiple manifestations in the central nervous system, remains a limited …
morbidities and multiple manifestations in the central nervous system, remains a limited …
[HTML][HTML] Decreased miR-451a in cerebrospinal fluid, a marker for both cognitive impairment and depressive symptoms in Alzheimer's disease
H Feng, P Hu, Y Chen, H Sun, J Cai, X He, Q Cao… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Alzheimer's disease (AD) patients are often accompanied by depressive
symptoms, but its underlying mechanism remains unclear. The present study aimed to …
symptoms, but its underlying mechanism remains unclear. The present study aimed to …
[HTML][HTML] Disturbance of neuron–microglia crosstalk mediated by GRP78 in Neuropsychiatric systemic lupus erythematosus mice
J Xu, C Yang, S Zeng, X Wang, P Yang… - Journal of …, 2023 - Springer
Objectives Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious phenotype
of systemic lupus erythematosus (SLE). The disturbance of neuron–microglia crosstalk is …
of systemic lupus erythematosus (SLE). The disturbance of neuron–microglia crosstalk is …
The Role of N6‐Methyladenosine in Inflammatory Diseases
H Xu, C Lin, J Yang, X Chen, Y Chen… - Oxidative Medicine …, 2022 - Wiley Online Library
N6‐Methyladenosine (m6A) is the most abundant epigenetic RNA modification in
eukaryotes, regulating RNA metabolism (export, stability, translation, and decay) in cells …
eukaryotes, regulating RNA metabolism (export, stability, translation, and decay) in cells …
Implications of Inflammatory Processes on a Developing Central Nervous System in Childhood‐Onset Systemic Lupus Erythematosus
H Van der Heijden, V Rameh, E Golden… - Arthritis & …, 2024 - Wiley Online Library
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is increasingly
affecting pediatric and adult populations. Neuropsychiatric manifestations (ie, cognitive …
affecting pediatric and adult populations. Neuropsychiatric manifestations (ie, cognitive …
[HTML][HTML] Locus coeruleus tyrosine hydroxylase positive neurons mediated the peripheral and central therapeutic effects of transcutaneous auricular vagus nerve …
H Lv, X Yu, P Wang, M Luo, Y Luo, H Lu, K Wang, A Xi… - Brain Stimulation, 2024 - Elsevier
Objective This study aims to investigate the effects of transcutaneous auricular vagus nerve
stimulation (taVNS) on the development of systemic lupus erythematosus (SLE) in MRL/lpr …
stimulation (taVNS) on the development of systemic lupus erythematosus (SLE) in MRL/lpr …