Proton therapy treatments are based on a proton RBE (relative biological effectiveness)
relative to high-energy photons of 1.1. The use of this generic, spatially invariant RBE within …

Charged particle therapy has been largely driven and influenced by nuclear physics. The
increase in energy deposition density along the ion path in the body allows reducing the …

Purpose This paper covers recent developments and applications of the TOPAS TOol for
PArticle Simulation and presents the approaches used to disseminate TOPAS. Materials and …

Background Geant4 is a Monte Carlo code extensively used in medical physics for a wide
range of applications, such as dosimetry, micro‐and nanodosimetry, imaging, radiation …

Proton therapy treatments are currently planned and delivered using the assumption that the
proton relative biological effectiveness (RBE) relative to photons is 1.1. This assumption …

The TOPAS Monte Carlo (MC) system is used in radiation therapy and medical imaging
research, having played a significant role in making Monte Carlo simulations widely …

Hadron therapy allows for highly conformal dose distributions and better sparing of organs-
at-risk, thanks to the characteristic dose deposition as function of depth. However, the quality …

Gold nanoparticles (GNPs) have shown potential to be used as a radiosensitizer for
radiation therapy. Despite extensive research activity to study GNP radiosensitization using …

Purpose To investigate if radiographic imaging changes defined as necrosis correlate with
regions in the brain with elevated linear energy transfer (LET) for proton radiation therapy …

This paper presents the first demonstration of deeply penetrating dose delivery using
focused very high energy electron (VHEE) beams using quadrupole magnets in Monte Carlo …