Progranulin is an evolutionarily conserved protein that has been implicated in human
neurodevelopmental and neurodegenerative diseases. Human progranulin is comprised of …

Heterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary
frontotemporal dementia. The mechanisms linking frontotemporal dementia pathogenesis to …

Heterozygous GRN (progranulin) mutations cause frontotemporal dementia (FTD) due to
haploinsufficiency, and increasing progranulin levels is a major therapeutic goal. Several …

Transcriptional dysregulation is a hallmark of numerous neurological disorders, offering
targetable pathways with the potential to alter disease progression substantially. This …

The realm of RNA has evolved beyond its conventional role as a passive carrier of genetic
information within molecular biology. It has now emerged as a captivating domain, arranging …