Gastric cancer

E Van Cutsem, X Sagaert, B Topal, K Haustermans… - The Lancet, 2016 - thelancet.com
Gastric cancer is one of the leading causes of cancer-related death worldwide. Many
patients have inoperable disease at diagnosis or have recurrent disease after resection with …

Metaplasia: tissue injury adaptation and a precursor to the dysplasia–cancer sequence

V Giroux, AK Rustgi - Nature Reviews Cancer, 2017 - nature.com
Metaplasia is the replacement of one differentiated somatic cell type with another
differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by …

Diagnostic methods for Helicobacter pylori infection: ideals, options, and limitations

P Sabbagh, M Mohammadnia-Afrouzi… - European Journal of …, 2019 - Springer
Helicobacter pylori (H. pylori) resides in the stomach, colonizes gastric epithelium, and
causes several digestive system diseases. Several diagnostic methods utilizing invasive or …

Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression

P Díaz, M Valenzuela Valderrama, J Bravo… - Frontiers in …, 2018 - frontiersin.org
Helicobacter pylori (H. pylori) infection is the major risk factor associated with the
development of gastric cancer. The transition from normal mucosa to non-atrophic gastritis …

Chemotherapy for advanced gastric cancer

AD Wagner, NLX Syn, M Moehler… - Cochrane database …, 2017 - cochranelibrary.com
Background Gastric cancer is the fifth most common cancer worldwide. In" Western"
countries, most people are either diagnosed at an advanced stage, or develop a relapse …

Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial

SJ Dutton, DR Ferry, JM Blazeby, H Abbas… - The lancet …, 2014 - thelancet.com
Background Evidence is scarce for the effectiveness of therapies for oesophageal cancer
progressing after chemotherapy, and no randomised trials have been reported. We aimed to …

lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer

Y Liu, J Zhao, W Zhang, J Gan, C Hu, G Huang… - Scientific reports, 2015 - nature.com
Long non-coding RNAs (lncRNAs), which have evolved as important gene expression
modulators, are involved in human malignancies. The down-regulation of lncRNA growth …

Cancer-associated fibroblasts promote aggressive gastric cancer phenotypes via heat shock factor 1–mediated secretion of extracellular vesicles

N Grunberg, M Pevsner-Fischer, T Goshen-Lago… - Cancer research, 2021 - AACR
Gastric cancer is the third most lethal cancer worldwide, and evaluation of the genomic
status of gastric cancer cells has not translated into effective prognostic or therapeutic …

Characterization of the prognostic m6A-related lncRNA signature in gastric cancer

H Wang, Q Meng, B Ma - Frontiers in oncology, 2021 - frontiersin.org
N6-methyladenosine (m6A) is a common form of mRNA modification regulated by m6A RNA
methylation regulators and play an important role in the progression of gastric cancer (GC) …

Apatinib: a novel receptor tyrosine kinase inhibitor for the treatment of gastric cancer

G Roviello, A Ravelli, K Polom, R Petrioli, L Marano… - Cancer letters, 2016 - Elsevier
Metastatic gastric cancer is a lethal disease characterized by a very short overall survival,
underlining a critical need of new therapeutic options. Unfortunately, although several …