STAT proteins as novel targets for cancer therapy
R Catlett-Falcone, WS Dalton… - Current opinion in …, 1999 - journals.lww.com
Although the signal transducer and activator of transcription (STAT) proteins were originally
discovered through the study of interferon-induced responses, a large number of cytokines …
discovered through the study of interferon-induced responses, a large number of cytokines …
The dynamic interface of viruses with STATs
AR Harrison, GW Moseley - Journal of virology, 2020 - Am Soc Microbiol
Viruses commonly antagonize the antiviral type I interferon response by targeting signal
transducer and activator of transcription 1 (STAT1) and STAT2, key mediators of interferon …
transducer and activator of transcription 1 (STAT1) and STAT2, key mediators of interferon …
[HTML][HTML] The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape
C Vandermeulen, T O'grady, J Wayet, B Galvan… - PLoS …, 2021 - journals.plos.org
Viral infections are known to hijack the transcription and translation of the host cell.
However, the extent to which viral proteins coordinate these perturbations remains unclear …
However, the extent to which viral proteins coordinate these perturbations remains unclear …
[HTML][HTML] HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells
N Araya, T Sato, H Ando, U Tomaru… - The Journal of …, 2014 - Am Soc Clin Investig
Human T-lymphotropic virus type 1 (HTLV-1) is linked to multiple diseases, including the
neuroinflammatory disease HTLV-1–associated myelopathy/tropical spastic paraparesis …
neuroinflammatory disease HTLV-1–associated myelopathy/tropical spastic paraparesis …
Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK–STAT pathway in T cell leukemia
J Rajasingh, HP Raikwar, G Muthian, C Johnson… - Biochemical and …, 2006 - Elsevier
Adult T cell leukemia is an aggressive and frequently fatal malignancy that expressess
constitutively activated growth-signaling pathways in association with deregulated growth …
constitutively activated growth-signaling pathways in association with deregulated growth …
Deregulation of cell-signaling pathways in HTLV-1 infection
WW Hall, M Fujii - Oncogene, 2005 - nature.com
Human T-lymphotropic virus type 1 (HTLV-1) infection is associated with the clonal
expansion and transformation of mature T lymphocytes. While the mechanisms involved are …
expansion and transformation of mature T lymphocytes. While the mechanisms involved are …
Fyn is a novel target of (−)‐epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation
Z He, F Tang, S Ermakova, M Li, Q Zhao… - … in cooperation with …, 2008 - Wiley Online Library
The cancer preventive action of (−)‐epigallocatechin gallate (EGCG), found in green tea, is
strongly supported by epidemiology and laboratory research data. However, the mechanism …
strongly supported by epidemiology and laboratory research data. However, the mechanism …
HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains
T Ren, Y Takahashi, X Liu, TP Loughran, SC Sun… - Oncogene, 2015 - nature.com
The retroviral oncoprotein Tax from human T-cell leukemia virus type 1 (HTLV-1), an
etiological factor that causes adult T-cell leukemia and lymphoma, has a crucial role in …
etiological factor that causes adult T-cell leukemia and lymphoma, has a crucial role in …
[HTML][HTML] A central role for STAT3 in gammaherpesvirus-life cycle and-diseases
X Li, S Bhaduri-McIntosh - Frontiers in microbiology, 2016 - frontiersin.org
Having co-evolved with humans, herpesviruses have adapted to exploit the host molecular
machinery to ensure viral persistence. The cellular protein Signal Transducer and Activator …
machinery to ensure viral persistence. The cellular protein Signal Transducer and Activator …
Lentivirus infection in the brain induces matrix metalloproteinase expression: role of envelope diversity
JB Johnston, Y Jiang, G Van Marle, MB Mayne… - Journal of …, 2000 - Am Soc Microbiol
Infection of the brain by lentiviruses, including human immunodeficiency virus (HIV) and
feline immunodeficiency virus (FIV), causes inflammation and results in neurodegeneration …
feline immunodeficiency virus (FIV), causes inflammation and results in neurodegeneration …