Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention

YAR Mahaman, KS Embaye, F Huang, L Li, F Zhu… - Ageing research …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Non-invasive transcranial brain modulation for neurological disorders treatment: a narrative review

EA Mosilhy, EE Alshial, MM Eltaras, MMA Rahman… - Life Sciences, 2022 - Elsevier
Noninvasive brain stimulation/modulation is a rapidly emerging technique that has been
implemented in different clinical applications. The commonly noninvasive techniques used …

[HTML][HTML] Retinal pathological features and proteome signatures of Alzheimer's disease

Y Koronyo, A Rentsendorj, N Mirzaei, GC Regis… - Acta …, 2023 - Springer
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

Retinal biomarkers in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis

YJ Ge, W Xu, YN Ou, Y Qu, YH Ma, YY Huang… - Ageing Research …, 2021 - Elsevier
Background Retinal changes may reflect the pathophysiological processes in the central
nervous system and can be assessed by imaging modalities non-invasively. We aim to …

[HTML][HTML] Retinal vasculopathy in Alzheimer's disease

H Shi, Y Koronyo, A Rentsendorj, DT Fuchs… - Frontiers in …, 2021 - frontiersin.org
The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …

[HTML][HTML] Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies

PA Constable, JKH Lim, DA Thompson - Frontiers in Neuroscience, 2023 - frontiersin.org
The retina and brain share similar neurochemistry and neurodevelopmental origins, with the
retina, often viewed as a “window to the brain.” With retinal measures of structure and …

[HTML][HTML] Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ …

H Shi, Z Yin, Y Koronyo, DT Fuchs, J Sheyn… - Acta neuropathologica …, 2022 - Springer
Single cell RNA sequencing studies identified novel neurodegeneration-associated
microglial (MGnD/DAM) subtypes activated around cerebral amyloid plaques. Micro-RNA …

Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer's disease: relevance for precision medicine in neurodegenerative diseases

S Lista, A Vergallo, SJ Teipel, P Lemercier… - Ageing research …, 2023 - Elsevier
Acetylcholinesterase inhibitors (ChEI) are the global standard of care for the symptomatic
treatment of Alzheimer's disease (AD) and show significant positive effects in …

[HTML][HTML] Proteostasis in aging-associated ocular disease

J Weinberg, M Gaur, A Swaroop, A Taylor - Molecular aspects of medicine, 2022 - Elsevier
Vision impairment has devastating consequences for the quality of human life. The cells and
tissues associated with the visual process must function throughout one's life span and …

[HTML][HTML] Role of retinal amyloid-β in neurodegenerative diseases: overlapping mechanisms and emerging clinical applications

L Wang, X Mao - International journal of molecular sciences, 2021 - mdpi.com
Amyloid-β (Aβ) accumulations have been identified in the retina for neurodegeneration-
associated disorders like Alzheimer's disease (AD), glaucoma, and age-related macular …