[HTML][HTML] The role of chondrocyte hypertrophy and senescence in osteoarthritis initiation and progression

YA Rim, Y Nam, JH Ju - International journal of molecular sciences, 2020 - mdpi.com
Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the
adult population. OA is primarily caused by trauma induced by an external force or by age …

Osteoarthritis pathogenesis: a review of molecular mechanisms

B Xia, D Chen, J Zhang, S Hu, H Jin, P Tong - Calcified tissue international, 2014 - Springer
Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with
age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal …

Mechanical stimulation of mesenchymal stem cells: Implications for cartilage tissue engineering

N Fahy, M Alini, MJ Stoddart - Journal of Orthopaedic Research …, 2018 - Wiley Online Library
Articular cartilage is a load‐bearing tissue playing a crucial mechanical role in diarthrodial
joints, facilitating joint articulation, and minimizing wear. The significance of biomechanical …

[HTML][HTML] Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects

EB Hunziker - Osteoarthritis and cartilage, 2002 - Elsevier
Objective To review the basic scientific status of repair in articular cartilage tissue and to
assess the efficiency of current clinical therapies instigated for the treatment of structural …

A Framework for the in Vivo Pathomechanics of Osteoarthritis at the Knee

TP Andriacchi, A Mündermann, RL Smith… - Annals of biomedical …, 2004 - Springer
The in vivo pathomechanics of osteoarthritis (OA) at the knee is described in a framework
that is based on an analysis of studies describing assays of biomarkers, cartilage …

Articular cartilage functional histomorphology and mechanobiology: a research perspective

M Wong, DR Carter - Bone, 2003 - Elsevier
The histomorphogenesis of articular cartilage is regulated during skeletal development by
the intermittent forces and motions imposed at diarthrodial joints. A key feature in this …

The mechanobiology of articular cartilage development and degeneration

DR Carter, GS Beaupré, M Wong… - Clinical Orthopaedics …, 2004 - journals.lww.com
The development, maintenance, and destruction of cartilage are regulated by mechanical
factors throughout life. Mechanical cues in the cartilage fetal endoskeleton influence the …

Rotational changes at the knee after ACL injury cause cartilage thinning.

TP Andriacchi, PL Briant, SL Bevill… - … and Related Research …, 2006 - journals.lww.com
We examined the relationship between specific gait changes after anterior cruciate ligament
injury and the progression of osteoarthritis at the knee. The study was done using a finite …

Patterning methods for polymers in cell and tissue engineering

HN Kim, DH Kang, MS Kim, A Jiao, DH Kim… - Annals of biomedical …, 2012 - Springer
Polymers provide a versatile platform for mimicking various aspects of physiological
extracellular matrix properties such as chemical composition, rigidity, and topography for …

[HTML][HTML] Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

F Wei, J Zhou, X Wei, J Zhang, BC Fleming… - Osteoarthritis and …, 2012 - Elsevier
OBJECTIVE: The objectives of this study were to (1) determine the correlation between
osteoarthritis (OA) and Indian hedgehog (Ihh) expression, and (2) establish the effects of Ihh …