[HTML][HTML] S-nitrosylation: an emerging paradigm of redox signaling
Nitric oxide (NO) is a highly reactive molecule, generated through metabolism of L-arginine
by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple …
by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple …
Mitochondria as a source of reactive oxygen and nitrogen species: from molecular mechanisms to human health
Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …
damaging pathways in different tissues. In addition, mitochondria are an important target of …
[图书][B] Oxidation and antioxidants in organic chemistry and biology
ET Denisov, IB Afanas' ev - 2005 - taylorfrancis.com
Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …
compounds and polymers, and biological processes mediated by free radicals, Oxidation …
[HTML][HTML] Mitochondria and reactive oxygen species: physiology and pathophysiology
S Bolisetty, EA Jaimes - International journal of molecular sciences, 2013 - mdpi.com
The air that we breathe contains nearly 21% oxygen, most of which is utilized by
mitochondria during respiration. While we cannot live without it, it was perceived as a bane …
mitochondria during respiration. While we cannot live without it, it was perceived as a bane …
The Yin and Yang of NMDA receptor signalling
GE Hardingham, H Bading - Trends in neurosciences, 2003 - cell.com
Ca 2+ entry through the NMDA subtype of glutamate receptors has the power to determine
whether neurons survive or die. Too much NMDA receptor activity is harmful to neurons–but …
whether neurons survive or die. Too much NMDA receptor activity is harmful to neurons–but …
[HTML][HTML] Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia
K Niizuma, H Yoshioka, H Chen, GS Kim… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Mitochondria play important roles as the powerhouse of the cell. After cerebral ischemia,
mitochondria overproduce reactive oxygen species (ROS), which have been thoroughly …
mitochondria overproduce reactive oxygen species (ROS), which have been thoroughly …
Nitric oxide signaling: classical, less classical, and nonclassical mechanisms
Although nitric oxide (NO) was identified more than 150 years ago and its effects were
clinically tested in the form of nitroglycerine, it was not until the decades of 1970–1990 that it …
clinically tested in the form of nitroglycerine, it was not until the decades of 1970–1990 that it …
Mitochondrial nitric oxide synthase
P Ghafourifar, E Cadenas - Trends in pharmacological sciences, 2005 - cell.com
Mitochondria produce nitric oxide (NO) through a Ca 2+-sensitive mitochondrial NO
synthase (mtNOS). The NO produced by mtNOS regulates mitochondrial oxygen …
synthase (mtNOS). The NO produced by mtNOS regulates mitochondrial oxygen …
Identification of the enzymatic mechanism of nitroglycerin bioactivation
Z Chen, J Zhang, JS Stamler - Proceedings of the National …, 2002 - National Acad Sciences
Nitroglycerin (glyceryl trinitrate, GTN), originally manufactured by Alfred Nobel, has been
used to treat angina and heart failure for over 130 years. However, the molecular …
used to treat angina and heart failure for over 130 years. However, the molecular …
[HTML][HTML] Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental …
S Najjar, DM Pearlman, O Devinsky, A Najjar… - Journal of …, 2013 - Springer
About one-third of people with major depressive disorder (MDD) fail at least two
antidepressant drug trials at 1 year. Together with clinical and experimental evidence …
antidepressant drug trials at 1 year. Together with clinical and experimental evidence …