Epigenetic disorders such as point mutations in cellular tumor suppressor genes, DNA
methylation and post-translational modifications are needed to transformation of normal …

Sarcoidosis is a systemic inflammatory disorder of unknown etiology characterized by tissue
infiltration with macrophages and lymphocytes and associated non-caseating granuloma …

Rationale: Pulmonary sarcoidosis is classically defined by T-helper (Th) cell type 1
inflammation (eg, IFN-γ production by CD4+ effector T cells). Recently, IL-17A–secreting …

Monoclonal antibody (mAb) therapy was first established upon the approval of a mouse
antibody for treatment of human acute organ rejection. However, the high incidence of …

Sarcoidosis is a multisystem granulomatous disorder that most often affects the lungs and
may cause significant morbidity. Sarcoidosis can manifest as neurological disease, uveitis …

Background Bronchial asthma is associated with an inflammatory process that is
characterized by the presence in the airways of large numbers of CD4+ T cells producing …

Sarcoidosis is characterised by non-caseating granulomas that secrete pro-inflammatory
cytokines, including interleukin (IL)-12, IL-23, and tumour necrosis factor (TNF)-α …

CD14+ peripheral blood monocytes can differentiate into fibroblast-like cells called
fibrocytes, which are associated with and are at least partially responsible for wound healing …

Since sarcoidosis was first described more than a century ago, the etiologic determinants
causing this disease remain uncertain. Studies suggest that genetic, host immunologic, and …

Dendritic cells (DCs) are professional antigen presenting cells displaying the unique
capability to activate naïve T cells. DCs react to pathogen encounter also by the production …