The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …

Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs)
are all considered “Pancreatic cystic neoplasms (PCNs)” and show a varying risk of …

The three major mitogen-activated protein kinase (MAPK) pathways (ERK1/2, p38, and
JNK/SAPK) are upstream regulators of the nuclear receptor superfamily (NRSF). These …

ZNF462 haploinsufficiency is linked to Weiss–Kruszka syndrome, a genetic disorder
characterized by neurodevelopmental defects, including autism. Though conserved in …

Nuclear receptors are transcription factors with important functions in a variety of
physiological and pathological processes. Targeting glucocorticoid receptor (GR) activity …

The nuclear receptor liver receptor homolog-1 (LRH-1) has been shown to promote
apoptosis resistance in various tissues and disease contexts; however, its role in liver cell …

Abstract Liver receptor homolog-1 (LRH-1, Nr5a2) is an orphan nuclear receptor mainly
expressed in tissues of endodermal origin, where its physiological role has been extensively …

Abstract Liver receptor homolog‐1 (LRH‐1, NR5A2) is an orphan nuclear receptor with
widespread activities in the regulation of development, stemness, metabolism …

Advances in technology are only beginning to reveal the complex interactions between
hosts and their resident microbiota that have co-evolved over centuries. In this review, we …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease that targets the destruction of
islet beta-cells resulting in insulin deficiency, hyperglycemia and death if untreated. Despite …