Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation
The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …
Clinical and molecular attributes and evaluation of pancreatic cystic neoplasm
P Raut, RK Nimmakayala, SK Batra… - Biochimica et Biophysica …, 2023 - Elsevier
Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs)
are all considered “Pancreatic cystic neoplasms (PCNs)” and show a varying risk of …
are all considered “Pancreatic cystic neoplasms (PCNs)” and show a varying risk of …
Mitogen-activated protein kinase and exploratory nuclear receptor crosstalk in cancer immunotherapy
E Burgermeister - International Journal of Molecular Sciences, 2023 - mdpi.com
The three major mitogen-activated protein kinase (MAPK) pathways (ERK1/2, p38, and
JNK/SAPK) are upstream regulators of the nuclear receptor superfamily (NRSF). These …
JNK/SAPK) are upstream regulators of the nuclear receptor superfamily (NRSF). These …
ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers
R Yelagandula, K Stecher, M Novatchkova… - Nature cell …, 2023 - nature.com
ZNF462 haploinsufficiency is linked to Weiss–Kruszka syndrome, a genetic disorder
characterized by neurodevelopmental defects, including autism. Though conserved in …
characterized by neurodevelopmental defects, including autism. Though conserved in …
LRH‐1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance
S Michalek, T Goj, AP Plazzo, B Marovca… - EMBO …, 2022 - embopress.org
Nuclear receptors are transcription factors with important functions in a variety of
physiological and pathological processes. Targeting glucocorticoid receptor (GR) activity …
physiological and pathological processes. Targeting glucocorticoid receptor (GR) activity …
[HTML][HTML] Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death
R Lambrecht, ME Delgado, V Gloe, K Schuetz… - Cell Reports, 2023 - cell.com
The nuclear receptor liver receptor homolog-1 (LRH-1) has been shown to promote
apoptosis resistance in various tissues and disease contexts; however, its role in liver cell …
apoptosis resistance in various tissues and disease contexts; however, its role in liver cell …
Pharmacological LRH-1/Nr5a2 inhibition limits pro-inflammatory cytokine production in macrophages and associated experimental hepatitis
Abstract Liver receptor homolog-1 (LRH-1, Nr5a2) is an orphan nuclear receptor mainly
expressed in tissues of endodermal origin, where its physiological role has been extensively …
expressed in tissues of endodermal origin, where its physiological role has been extensively …
Nuclear‐mitochondrial crosstalk: on the role of the nuclear receptor liver receptor homolog‐1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival, and …
S Michalek, T Brunner - IUBMB life, 2021 - Wiley Online Library
Abstract Liver receptor homolog‐1 (LRH‐1, NR5A2) is an orphan nuclear receptor with
widespread activities in the regulation of development, stemness, metabolism …
widespread activities in the regulation of development, stemness, metabolism …
Gut feelings about bacterial steroid-17, 20-desmolase
Advances in technology are only beginning to reveal the complex interactions between
hosts and their resident microbiota that have co-evolved over centuries. In this review, we …
hosts and their resident microbiota that have co-evolved over centuries. In this review, we …
[HTML][HTML] Time for a paradigm shift in treating type 1 diabetes mellitus: coupling inflammation to islet regeneration
N Cobo-Vuilleumier, BR Gauthier - Metabolism, 2020 - Elsevier
Type 1 diabetes mellitus (T1DM) is an autoimmune disease that targets the destruction of
islet beta-cells resulting in insulin deficiency, hyperglycemia and death if untreated. Despite …
islet beta-cells resulting in insulin deficiency, hyperglycemia and death if untreated. Despite …