Peripheral immune function and Alzheimer's disease: a living systematic review and critical appraisal

C Li, RC Stebbins, GA Noppert, CX Carney, C Liu… - Molecular …, 2023 - nature.com
Background A growing body of literature examines the relationship between peripheral
immune function and Alzheimer's Disease (AD) in human populations. Our living systematic …

Circulating biomarkers of inflammaging and Alzheimer's disease to track age-related trajectories of dementia: Can we develop a clinically relevant composite …

AM Abbatecola, A Giuliani, L Biscetti, L Scisciola… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) is a rapidly growing global concern due to a consistent rise of the
prevalence of dementia which is mainly caused by the aging population worldwide. An early …

CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly

F Shue, LJ White, R Hendrix, J Ulrich, RL Henson… - Science …, 2024 - science.org
The immune system substantially influences age-related cognitive decline and Alzheimer's
disease (AD) progression, affected by genetic and environmental factors. In a Mayo Clinic …

Association of peripheral B cells and delirium: combined single-cell sequencing and Mendelian randomization analysis

S Tan, S Pan, L Wei, W Chen, B Pan, G Kong… - Frontiers in …, 2024 - frontiersin.org
Background Delirium seriously affects the prognosis of patients and greatly reduces the
ability to work and live. Peripheral inflammatory events may contribute to the development of …

[HTML][HTML] Research progress in Alzheimer's disease and bone-brain axis

F Zhang, W Zhang - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) is the most common type of cognitive impairment. AD is closely
related to orthopedic diseases, such as osteoporosis and osteoarthritis, in terms of …

Blood‐based inflammatory protein biomarker panel for the prediction of relapse and severity in patients with neuromyelitis optica spectrum disorder: A prospective …

Q Wei, J Li, C Zhao, S Meng, N Liu, Z Wu… - CNS Neuroscience …, 2024 - Wiley Online Library
Background To date, most existing models for predicting neuromyelitis optica spectrum
disorder (NMOSD) are based primarily on clinical characteristics. Blood‐based NMOSD …

Methods and clinical biomarker discovery for targeted proteomics using Olink technology

H Wang, T Zhao, J Zeng, R Zhang, L Pu… - PROTEOMICS …, 2024 - Wiley Online Library
Purpose This paper is to offer insights for designing research utilizing Olink technology to
identify biomarkers and potential therapeutic targets for disease treatment. Experimental …

[HTML][HTML] Proteome-wide association studies using summary proteomic data identified 23 risk genes of Alzheimer's disease

T Hu, Q Dai, MP Epstein, J Yang - medRxiv, 2024 - ncbi.nlm.nih.gov
Characterizing the genetic mechanisms underlying Alzheimer's disease (AD) dementia is
crucial for developing new therapeutics. Proteome-wide association study (PWAS) …

Circulating inflammatory proteins may be potential drug targets for Idiopathic Membranous Nephropathy: proteome-wide Mendelian Randomization and colocalization …

Z Su, Q Rao, D Wu, Z Yin, W Liu, Q Wan - medRxiv, 2023 - medrxiv.org
Background: Idiopathic membranous nephropathy (IMN) is a predominant cause of
nephrotic syndrome among adults. Existing drugs are ineffective in about one-third of IMN …

[HTML][HTML] Aging-Related Immune Cell Phenotypes and Mortality in the Framingham Heart Study

AAY Ragab, MF Doyle, J Chen, Y Fang… - Research …, 2023 - ncbi.nlm.nih.gov
Background The global increase in human life expectancy is evident. The total number of
individuals aged 60 or above is anticipated to reach 2 billion by 2050. Aging, an inherently …