Signaling by cGAS–STING in neurodegeneration, neuroinflammation, and aging
Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …
Microglia in retinal degeneration
K Rashid, I Akhtar-Schaefer, T Langmann - Frontiers in immunology, 2019 - frontiersin.org
The retina is a complex tissue with multiple cell layers that are highly ordered. Its
sophisticated structure makes it especially sensitive to external or internal perturbations that …
sophisticated structure makes it especially sensitive to external or internal perturbations that …
The lung microbiome regulates brain autoimmunity
L Hosang, RC Canals, FJ van der Flier, J Hollensteiner… - Nature, 2022 - nature.com
Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated
autoimmune disease of the central nervous system. In addition, the lung serves as a niche …
autoimmune disease of the central nervous system. In addition, the lung serves as a niche …
Novel Hexb-based tools for studying microglia in the CNS
Microglia and central nervous system (CNS)-associated macrophages (CAMs), such as
perivascular and meningeal macrophages, are implicated in virtually all diseases of the …
perivascular and meningeal macrophages, are implicated in virtually all diseases of the …
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
V Rothhammer, ID Mascanfroni, L Bunse… - Nature medicine, 2016 - nature.com
Astrocytes have important roles in the central nervous system (CNS) during health and
disease. Through genome-wide analyses we detected a transcriptional response to type I …
disease. Through genome-wide analyses we detected a transcriptional response to type I …
Regulation of type I interferon responses
LB Ivashkiv, LT Donlin - Nature Reviews Immunology, 2014 - nature.com
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …
development of innate and adaptive immune responses. Canonical type I IFN signalling …
Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through FcγR engagement and type I interferon signaling
Despite the clinical success of checkpoint inhibitors, a substantial gap still exists in our
understanding of their mechanism of action. While antibodies to cytotoxic T lymphocyte …
understanding of their mechanism of action. While antibodies to cytotoxic T lymphocyte …
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Mononuclear phagocytic cells in the CNS used to be defined according to their anatomical
location and surface marker expression. Recently, this concept has been challenged by the …
location and surface marker expression. Recently, this concept has been challenged by the …
Aging-induced type I interferon response at the choroid plexus negatively affects brain function
Aging-associated cognitive decline is affected by factors produced inside and outside the
brain. By using multiorgan genome-wide analysis of aged mice, we found that the choroid …
brain. By using multiorgan genome-wide analysis of aged mice, we found that the choroid …
Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease
SS Iyer, G Cheng - Critical Reviews™ in Immunology, 2012 - dl.begellhouse.com
ABSTRACT Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that
plays a central role in limiting host immune response to pathogens, thereby preventing …
plays a central role in limiting host immune response to pathogens, thereby preventing …