Background Studies evaluating the relationship between chronic inflammation and cognitive
functioning have produced heterogeneous results. A potential reason for this is the …

Alzheimer's disease (AD) is the most common dementia disorder. While genetic mutations
account for only 1% of AD cases, sporadic AD resulting from a combination of genetic and …

Chronological age estimation may offer valuable investigative leads in human identification
cases. Bisulfite pyrosequencing analysis of single CpG sites on five genes (KLF14, ELOVL2 …

Objective This study tests associations of DNA methylation-based (DNAm) measures of
epigenetic age acceleration (EAA) with cross-sectional and longitudinal depressive …

A century of conceptual and technological advances in infectious disease research has
changed the face of medicine. However, there remains a lack of effective interventions and a …

ABSTRACT The Developmental Origins of Health and Disease (DOHaD) theory predicts that
prenatal and early life events shape adult health outcomes. Birth weight is a useful indicator …

Methylation levels measured at defined sites across the genome have recently been shown
to be correlated with an individual's chronological age. Age acceleration, or the difference …

Hypertension is a disease associated with epigenetic aging. However, the pathogenic
mechanism underlying this relationship remains unclear. We aimed to characterize the …

Background Both parental and neighbourhood socio-economic status (SES) are linked to
poorer health independently of personal SES measures, but the biological mechanisms are …

It is well recognized that not all individuals age equivalently, with functional dependence
attributable, at least in part, to stress accumulated across the lifespan. Amongst these …