It is well recognized that not all individuals age equivalently, with functional dependence
attributable, at least in part, to stress accumulated across the lifespan. Amongst these …

Objective Posttraumatic stress disorder (PTSD) has been related to accelerated biological
aging processes, but objective evidence for this association is limited. DNA methylation …

Age-associated DNA methylation in blood cells convey information on health status.
However, the mechanisms that drive these changes in circulating cells and their …

Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common
form of dementia. There are two main types of AD: familial and sporadic. Familial AD is …

Epigenetic modifications have been implicated in a number of complex diseases as well as
being a hallmark of organismal aging. Several reports have indicated an involvement of …

Background: Alzheimer disease (AD) is the most common neurodegenerative disease of the
central nervous system. The stability of the telomere-telomerase system is closely related to …

We investigated whether lifestyle influences epigenetic aging in 143 monozygotic twin pairs
discordant for the combined healthy lifestyle score. Twins were scored for four lifestyle …

The causative mechanisms underlying the genetic relationships of neurodegenerative
diseases with epigenetic aging and human longevity remain obscure. We aimed to detect …

Propensity score (PS) methods are popular when estimating causal effects in non-
randomized studies. Drawing causal conclusion relies on the unconfoundedness …

Background: Genetic and epigenetic changes, oxidative stress and inflammation influence
the rate of aging, which diseases, lifestyle and environmental factors can further accelerate …