Targeting infectious agents as a therapeutic strategy in Alzheimer's disease
Alzheimer's disease (AD) is the most prevalent dementia in the world. Its cause (s) are
presently largely unknown. The most common explanation for AD, now, is the amyloid …
presently largely unknown. The most common explanation for AD, now, is the amyloid …
Expansion of rare and harmful lineages is associated with established rheumatoid arthritis
N Mena-Vázquez, P Ruiz-Limón… - Journal of Clinical …, 2020 - mdpi.com
Objectives: To characterize the gut microbiota profile in rheumatoid arthritis (RA) patients
and investigate its association with certain characteristics of RA. Patients and methods: A …
and investigate its association with certain characteristics of RA. Patients and methods: A …
Disease mechanisms in preclinical rheumatoid arthritis: A narrative review
VC Romão, JE Fonseca - Frontiers in Medicine, 2022 - frontiersin.org
In the last decades, the concept of preclinical rheumatoid arthritis (RA) has become
established. In fact, the discovery that disease mechanisms start years before the onset of …
established. In fact, the discovery that disease mechanisms start years before the onset of …
Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European …
BA Fisher, AJ Cartwright, AM Quirke, P de Pablo… - BMC musculoskeletal …, 2015 - Springer
Background Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis.
Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a …
Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a …
[HTML][HTML] A roadmap of the generation of neoantigens as targets of the immune system in type 1 diabetes
BO Roep, MJL Kracht, M van Lummel… - Current opinion in …, 2016 - Elsevier
Highlights•Beta cells communicate with other endocrine cells and immune cells during the
course of T1D.•Beta cells contribute to their own demise by generating neoantigens targeted …
course of T1D.•Beta cells contribute to their own demise by generating neoantigens targeted …
Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10. RIII mice
S Chukkapalli, M Rivera-Kweh, P Gehlot… - Arthritis research & …, 2016 - Springer
Background It has been previously hypothesized that oral microbes may be an etiological
link between rheumatoid arthritis (RA) and periodontal disease. However, the mechanistic …
link between rheumatoid arthritis (RA) and periodontal disease. However, the mechanistic …
Influence of anti‐rheumatic agents on the periodontal condition of patients with rheumatoid arthritis and periodontitis: A systematic review and meta‐analysis
J Zhang, C Xu, L Gao, D Zhang, C Li… - Journal of Periodontal …, 2021 - Wiley Online Library
Objective To evaluate the influence of diverse anti‐rheumatic agents on the periodontal
condition and to provide clinical medication guidance for patients with rheumatoid arthritis …
condition and to provide clinical medication guidance for patients with rheumatoid arthritis …
The P. gingivalis Autocitrullinome Is Not a Target for ACPA in Early Rheumatoid Arthritis
E Muñoz-Atienza, MB Flak, J Sirr… - Journal of dental …, 2020 - journals.sagepub.com
Rheumatoid arthritis (RA), a chronic inflammatory disease affecting primarily the joints, is
frequently characterized by the presence of autoimmune anticitrullinated protein antibodies …
frequently characterized by the presence of autoimmune anticitrullinated protein antibodies …
Microbe-metabolite-host axis, two-way action in the pathogenesis and treatment of human autoimmunity
X Meng, HY Zhou, HH Shen, E Lufumpa, XM Li… - Autoimmunity …, 2019 - Elsevier
The role of microorganism in human diseases cannot be ignored. These microorganisms
have evolved together with humans and worked together with body's mechanism to maintain …
have evolved together with humans and worked together with body's mechanism to maintain …
Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights
Research on the influence of gut microbiota on systemic inflammatory arthritis has exploded
in the past decade. Gut microbiota changes may be a crucial regulatory component in …
in the past decade. Gut microbiota changes may be a crucial regulatory component in …