Targeting infectious agents as a therapeutic strategy in Alzheimer's disease

T Fülöp, U Munawara, A Larbi, M Desroches… - CNS drugs, 2020 - Springer
Alzheimer's disease (AD) is the most prevalent dementia in the world. Its cause (s) are
presently largely unknown. The most common explanation for AD, now, is the amyloid …

Expansion of rare and harmful lineages is associated with established rheumatoid arthritis

N Mena-Vázquez, P Ruiz-Limón… - Journal of Clinical …, 2020 - mdpi.com
Objectives: To characterize the gut microbiota profile in rheumatoid arthritis (RA) patients
and investigate its association with certain characteristics of RA. Patients and methods: A …

Disease mechanisms in preclinical rheumatoid arthritis: A narrative review

VC Romão, JE Fonseca - Frontiers in Medicine, 2022 - frontiersin.org
In the last decades, the concept of preclinical rheumatoid arthritis (RA) has become
established. In fact, the discovery that disease mechanisms start years before the onset of …

Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European …

BA Fisher, AJ Cartwright, AM Quirke, P de Pablo… - BMC musculoskeletal …, 2015 - Springer
Background Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis.
Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a …

[HTML][HTML] A roadmap of the generation of neoantigens as targets of the immune system in type 1 diabetes

BO Roep, MJL Kracht, M van Lummel… - Current opinion in …, 2016 - Elsevier
Highlights•Beta cells communicate with other endocrine cells and immune cells during the
course of T1D.•Beta cells contribute to their own demise by generating neoantigens targeted …

Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10. RIII mice

S Chukkapalli, M Rivera-Kweh, P Gehlot… - Arthritis research & …, 2016 - Springer
Background It has been previously hypothesized that oral microbes may be an etiological
link between rheumatoid arthritis (RA) and periodontal disease. However, the mechanistic …

Influence of anti‐rheumatic agents on the periodontal condition of patients with rheumatoid arthritis and periodontitis: A systematic review and meta‐analysis

J Zhang, C Xu, L Gao, D Zhang, C Li… - Journal of Periodontal …, 2021 - Wiley Online Library
Objective To evaluate the influence of diverse anti‐rheumatic agents on the periodontal
condition and to provide clinical medication guidance for patients with rheumatoid arthritis …

The P. gingivalis Autocitrullinome Is Not a Target for ACPA in Early Rheumatoid Arthritis

E Muñoz-Atienza, MB Flak, J Sirr… - Journal of dental …, 2020 - journals.sagepub.com
Rheumatoid arthritis (RA), a chronic inflammatory disease affecting primarily the joints, is
frequently characterized by the presence of autoimmune anticitrullinated protein antibodies …

Microbe-metabolite-host axis, two-way action in the pathogenesis and treatment of human autoimmunity

X Meng, HY Zhou, HH Shen, E Lufumpa, XM Li… - Autoimmunity …, 2019 - Elsevier
The role of microorganism in human diseases cannot be ignored. These microorganisms
have evolved together with humans and worked together with body's mechanism to maintain …

Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights

B Li, B Yang, X Liu, J Zhao, RP Ross, C Stanton… - Cellular and Molecular …, 2022 - Springer
Research on the influence of gut microbiota on systemic inflammatory arthritis has exploded
in the past decade. Gut microbiota changes may be a crucial regulatory component in …