The success of inhalation therapy is not only dependent upon the pharmacology of the
drugs being inhaled but also upon the site and extent of deposition in the respiratory tract …

All patients with asthma are at risk of having exacerbations. Hospitalizations and emergency
department (ED) visits account for a large proportion of the health-care cost burden of …

Acute severe asthma remains a major economic and health burden. The natural history of
acute decompensations is one of resolution and only about 0.4% of patients succumb …

Nebulizers convert solutions or suspensions into aerosols with a particle size that can be
inhaled into the lower respiratory tract. There are pneumatic jet nebulizers, ultrasonic …

Background Helium and oxygen mixtures (heliox), have been used sporadically in
respiratory medicine for decades. Their use in acute respiratory emergencies such as …

Medical gases are pharmaceutical molecules which offer solutions to a wide array of
medical needs. This can range from use in burn and stroke victims to hypoxia therapy in …

Abstract Development of a new drug for the treatment of lung disease is a complex and time
consuming process involving numerous disciplines of basic and applied sciences. During …

The pathophysiology of high-altitude illnesses has been well studied in normal individuals,
but little is known about the risks of high-altitude travel in patients with pre-existing lung …

Background Acute severe asthma induces marked alterations in respiratory mechanics,
characterized by a critical limitation of expiratory flow and a heterogeneous and reversible …

Background The effect of heliox as a nebulizer β 2-agonist driving gas in acute asthma
remains controversial. Objective To perform a systematic review with a meta-analysis of …