In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a salient attribute of
many human diseases including obesity, liver disorders, cancer, diabetes and …

Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …

The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling
network which is activated in response to intrinsic and extrinsic stresses. Various stresses …

Solid tumors often grow in a micro-environment characterized by< 2% O 2 tension. This
condition, together with the aberrant activation of specific oncogenic patwhays, increases …

The unfolded protein response (UPR) is an adaptive cellular program used by eukaryotic
cells to cope with protein misfolding stress. During tumor development, cancer cells are …

The MYC transcription factor, encoded by the c‐MYC proto‐oncogene, is activated by
growth‐promoting signals, and is a key regulator of biosynthetic and metabolic pathways …

Intrinsically disordered proteins (IDPs) do not have a well-defined structure under
physiological conditions, but they have key roles in cell signaling and regulation, and they …

BH3-mimetics are a new class of anti-cancer drugs that inhibit anti-apoptotic Bcl-2 proteins.
In doing so, BH3-mimetics sensitise to cell death. Venetoclax is a potent, BCL-2 selective …

Ferroptosis is an iron-dependent cell death characterized by the accumulation of
hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces …