Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high metastasis
and therapeutic resistance. Activating transcription factor 4 (ATF4), a master regulator of …

During their quest for growth, adaptation, and survival, cancer cells create a favorable
environment through the manipulation of normal cellular mechanisms. They increase …

Methamphetamine (METH) is an illegal and widely abused psychoactive stimulant. METH
exposure causes detrimental effects on multiple organ systems, primarily the nervous …

The integrated stress response (ISR) facilitates cellular adaptation to unfavorable conditions
by reprogramming the cellular response. ISR activation was reported in neurological …

Simple Summary PDAC is one of the most malignant tumors and its treatment, whether
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …

Altered mRNA translational control is emerging as a critical factor in cancer development
and progression. Targeting specific elements of the translational machinery, such as …

Abstract Nuclear protein‑1 (NUPR1) is also known as Com‑1 or p8. It is a protein primarily
found in the nucleus of various cells, including cancer cells, and it has been found to play an …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal form of cancer with few therapeutic
options. We found that levels of the lysine methyltransferase SMYD2 (SET and MYND …

Cell division, differentiation and function are largely dependent on accurate proteome
composition and regulated gene expression. To control this, protein synthesis is an intricate …

The integrated stress response (ISR) pathway is essential for adaption of various stresses
and is related to mitochondrion-to-nucleus communication. Mitochondrial dysfunction …