Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium
Background Genome-wide association studies have identified three chromosomal regions
at 15q25, 5p15, and 6p21 as being associated with the risk of lung cancer. To confirm these …
at 15q25, 5p15, and 6p21 as being associated with the risk of lung cancer. To confirm these …
Genome-wide association studies of cancer
Knowledge of the inherited risk for cancer is an important component of preventive
oncology. In addition to well-established syndromes of cancer predisposition, much remains …
oncology. In addition to well-established syndromes of cancer predisposition, much remains …
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14
E Ruark, S Seal, H McDonald, F Zhang, A Elliot… - Nature …, 2013 - nature.com
Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable
for its high familial risks,. So far, six loci associated with TGCT have been reported,,,,. From …
for its high familial risks,. So far, six loci associated with TGCT have been reported,,,,. From …
[HTML][HTML] Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans
GWAS of prostate cancer have been remarkably successful in revealing common genetic
variants and novel biological pathways that are linked with its etiology. A more complete …
variants and novel biological pathways that are linked with its etiology. A more complete …
[HTML][HTML] Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk
score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the …
score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the …
[HTML][HTML] Proteomics of protein trafficking by in vivo tissue-specific labeling
IA Droujinine, AS Meyer, D Wang, ND Udeshi… - Nature …, 2021 - nature.com
Conventional approaches to identify secreted factors that regulate homeostasis are limited
in their abilities to identify the tissues/cells of origin and destination. We established a …
in their abilities to identify the tissues/cells of origin and destination. We established a …
[HTML][HTML] A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank
Background Multimorbidities greatly increase the global health burdens, but the landscapes
of their genetic risks have not been systematically investigated. Methods We used the …
of their genetic risks have not been systematically investigated. Methods We used the …
Genetic correction of PSA values using sequence variants associated with PSA levels
J Gudmundsson, S Besenbacher, P Sulem… - Science translational …, 2010 - science.org
Measuring serum levels of the prostate-specific antigen (PSA) is the most common
screening method for prostate cancer. However, PSA levels are affected by a number of …
screening method for prostate cancer. However, PSA levels are affected by a number of …
[HTML][HTML] Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis
G Sato, Y Shirai, S Namba, R Edahiro… - Nature …, 2023 - nature.com
Integrating genomic data of multiple cancers allows de novo cancer grouping and
elucidating the shared genetic basis across cancers. Here, we conduct the pan-cancer and …
elucidating the shared genetic basis across cancers. Here, we conduct the pan-cancer and …
[HTML][HTML] New basal cell carcinoma susceptibility loci
SN Stacey, H Helgason, SA Gudjonsson… - Nature …, 2015 - nature.com
In an ongoing screen for DNA sequence variants that confer risk of cutaneous basal cell
carcinoma (BCC), we conduct a genome-wide association study (GWAS) of 24,988,228 …
carcinoma (BCC), we conduct a genome-wide association study (GWAS) of 24,988,228 …