IMPLICATIONS: Postoperative morphine overconsumption occurred after large-dose
remifentanil and propofol anesthesia for major abdominal surgery during the early …

This paper is the twenty-fifth consecutive installment of the annual review of research
concerning the endogenous opioid system, now spanning over a quarter-century of …

It is widely accepted that chronic opioid therapy is associated with the development of
pharmacological tolerance. More controversial is the question as to whether acute opioid …

Концепция мультимодальной анальгезии, т. е. одновременного назначения нескольких
препаратов с различными механизмами действия, была разработана с целью …

STUDY OBJECTIVE: To examine the effects of background morphine infusion via patient-
controlled intravenous analgesia (PCA) device. DESIGN: Randomized, controlled, double …

En muchas ocasiones, los pacientes con cáncer no expresan su dolor por miedo a que el
médico desvíe su atención hacia este síntoma, en lugar de centrarse en el tratamiento de su …

Objective To evaluate the relationship between major heroin metabolites (morphine,
morphine-6-glucoronide), pattern of drug use, and late impairment of psychomotor functions …

Morphine for postoperative pain control is commonly titrated via intravenous patient-
controlled analgesia (IV-PCA). An IV morphine background infusion is rarely used. We …

Objective: To assess the effectiveness of opioid rotation (OR) to manage cancer pain. To
describe the adverse events (AEs) associated with OR. Setting: Thirty-nine tertiary hospital …

Background: Magnesium is a noncompetitive antagonist of the N-methyl-D aspartate
(NMDA) receptor. Magnesium is thought to be involved in opioid tolerance by way of …