Efficient release of promoter-proximally paused RNA Pol II into productive elongation is
essential for gene expression. Recently, we reported that the Integrator complex can bind …

Regulation by gene-distal enhancers is critical for cell type-specific and condition-specific
patterns of gene expression. Thus, to understand the basis of gene activity in a given cell …

The heat shock response (HSR) is critical for survival of all organisms. However, its scope,
extent, and the molecular mechanism of regulation are poorly understood. Here we show …

In eukaryotes, DNA is packed inside the cell nucleus in the form of chromatin, which consists
of DNA, proteins such as histones, and RNA. Euchromatin, which is permissive for …

RNA structure is intimately connected to each step of gene expression. Recent advances
have enabled transcriptome-wide maps of RNA secondary structure, called 'RNA …

The expansion of introns within mammalian genomes poses a challenge for the production
of full-length messenger RNAs (mRNAs), with increasing evidence that these long AT-rich …

Abstract Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by
phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects …

The transition of RNA polymerase II (Pol II) from initiation to productive elongation is a
central, regulated step in metazoan gene expression. At many genes, Pol II pauses stably in …

Chromosome organization poses a remarkable physical problem with many biological
consequences: How can molecular interactions between proteins at the nanometer scale …

Nuclear chromosomes transcribe far more RNA than required to encode protein. Here we
investigate whether non-coding RNA broadly contributes to cytological-scale chromosome …