[HTML][HTML] Widespread rearrangement of 3D chromatin organization underlies polycomb-mediated stress-induced silencing
Chromosomes of metazoan organisms are partitioned in the interphase nucleus into
discrete topologically associating domains (TADs). Borders between TADs are formed in …
discrete topologically associating domains (TADs). Borders between TADs are formed in …
Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate
Alternative splicing modulates expression of most human genes. The kinetic model of
cotranscriptional splicing suggests that slow elongation expands and that fast elongation …
cotranscriptional splicing suggests that slow elongation expands and that fast elongation …
[HTML][HTML] Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation
Cleavage and polyadenylation (CPA) is responsible for 3′ end processing of eukaryotic
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …
[HTML][HTML] CDK9-dependent RNA polymerase II pausing controls transcription initiation
S Gressel, B Schwalb, TM Decker, W Qin, H Leonhardt… - Elife, 2017 - elifesciences.org
Gene transcription can be activated by decreasing the duration of RNA polymerase II
pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we …
pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we …
[HTML][HTML] Control of RNA Pol II speed by PNUTS-PP1 and Spt5 dephosphorylation facilitates termination by a “sitting duck torpedo” mechanism
MA Cortazar, RM Sheridan, B Erickson, N Fong… - Molecular cell, 2019 - cell.com
Control of transcription speed, which influences many co-transcriptional processes, is poorly
understood. We report that PNUTS-PP1 phosphatase is a negative regulator of RNA …
understood. We report that PNUTS-PP1 phosphatase is a negative regulator of RNA …
[HTML][HTML] RNA Polymerase II cluster dynamics predict mRNA output in living cells
Protein clustering is a hallmark of genome regulation in mammalian cells. However, the
dynamic molecular processes involved make it difficult to correlate clustering with functional …
dynamic molecular processes involved make it difficult to correlate clustering with functional …
[HTML][HTML] Splicing of nascent RNA coincides with intron exit from RNA polymerase II
Protein-coding genes in eukaryotes are transcribed by RNA polymerase II (Pol II) and
introns are removed from pre-mRNA by the spliceosome. Understanding the time lag …
introns are removed from pre-mRNA by the spliceosome. Understanding the time lag …
[HTML][HTML] Integrator is a genome-wide attenuator of non-productive transcription
S Lykke-Andersen, K Žumer, EŠ Molska, JO Rouvière… - Molecular cell, 2021 - cell.com
Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the
cleavage and polyadenylation (CPA) and integrator (INT) complexes originally found to act …
cleavage and polyadenylation (CPA) and integrator (INT) complexes originally found to act …
[HTML][HTML] DOT1L and H3K79 methylation in transcription and genomic stability
The organization of eukaryotic genomes into chromatin provides challenges for the cell to
accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA …
accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA …
A practical view of fine-mapping and gene prioritization in the post-genome-wide association era
RV Broekema, OB Bakker, IH Jonkers - Open biology, 2020 - royalsocietypublishing.org
Over the past 15 years, genome-wide association studies (GWASs) have enabled the
systematic identification of genetic loci associated with traits and diseases. However, due to …
systematic identification of genetic loci associated with traits and diseases. However, due to …