Nucleosome organization influences gene activity by controlling DNA accessibility to
transcription machinery. Here, we develop a chemical biology approach to determine …

Steady-state gene expression across the cell cycle has been studied extensively. However,
transcriptional gene regulation and the dynamics of histone modification at different cell …

Abstract Cyclin-dependent kinase 9 (CDK9), the kinase component of positive transcription
elongation factor b (P-TEFb), is essential for transcription of most protein-coding genes by …

Reprogramming of transcription is critical for the survival under cellular stress. Heat shock
has provided an excellent model to investigate nascent transcription in stressed cells, but …

TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also
serves other important biological roles. Although much remains unknown about TFIIH …

Promoter-proximal pausing by RNA polymerase II (Pol II) is a well-established mechanism to
control the timing, rate, and possibly the magnitude of transcriptional responses. Recent …

The transcription cycle of RNA polymerase II (Pol II) is regulated by a set of cyclin-dependent
kinases (CDKs). Cdk7, associated with the transcription initiation factor TFIIH, is both an …

Common fragile sites (CFSs) are chromosome regions prone to breakage upon replication
stress known to drive chromosome rearrangements during oncogenesis. Most CFSs nest in …

Abstract DDX5 and DDX17 are DEAD-box RNA helicase paralogs which regulate several
aspects of gene expression, especially transcription and splicing, through incompletely …

Elongation factor Paf1C regulates several stages of the RNA polymerase II (Pol II)
transcription cycle, although it is unclear how it modulates Pol II distribution and progression …