Updates and advances in multiple sclerosis neurotherapeutics

M Amin, CM Hersh - Neurodegenerative disease management, 2023 - Taylor & Francis
The multiple sclerosis (MS) neurotherapeutic landscape is rapidly evolving. New disease-
modifying therapies (DMTs) with improved efficacy and safety, in addition to an expanding …

Translation of cell therapies to treat autoimmune disorders

JM Mehta, SC Hiremath, C Chilimba, A Ghasemi… - Advanced Drug Delivery …, 2023 - Elsevier
Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …

Regulatory T cell therapy for multiple sclerosis: Breaching (blood-brain) barriers

J Verreycken, P Baeten, B Broux - Human Vaccines & …, 2022 - Taylor & Francis
Multiple sclerosis (MS) is an autoimmune disorder causing demyelination and
neurodegeneration in the central nervous system. MS is characterized by disturbed motor …

Bruton's tyrosine kinase as a promising therapeutic target for multiple sclerosis

D Saberi, A Geladaris, S Dybowski… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Multiple sclerosis (MS) is the most common demyelinating disease of the central
nervous system (CNS). Although there are several disease-modifying therapies that can …

[HTML][HTML] Juvenile idiopathic arthritis, uveitis and multiple sclerosis: description of two patients and literature review

CB Chighizola, M Ferrito, L Marelli, I Pontikaki, P Nucci… - Biomedicines, 2022 - mdpi.com
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood, while
multiple sclerosis (MS) is a demyelinating disease of the central nervous system …

A new perspective on therapies involving B-cell depletion in autoimmune diseases

SIS Al-Hawary, SA Jasim, A Hjazi, H Ullah… - Molecular Biology …, 2024 - Springer
It has been rediscovered in the last fifteen years that B-cells play an active role in
autoimmune etiology rather than just being spectators. The clinical success of B-cell …

The Development of the Combination Drug Leukovir® Tablets for the Treatment of Multiple Sclerosis: A Comprehensive Review

EN Kalinichenko, SV Babitskaya - Current Drug Targets, 2023 - ingentaconnect.com
Introduction: Rosa webbiana (RW) Wall Ex. Royle is used in traditional medicine in Pakistan
for the treatment of several diseases including jaundice. To date, only neuroprotective …

[HTML][HTML] Mapping the Therapeutic Options for Multiple Sclerosis in Brazil: A Comprehensive Analysis

CS Desidério, YM Pessoa-Gonçalves, RO Trevisan… - Sclerosis, 2024 - mdpi.com
Multiple sclerosis is an autoimmune disease that affects the central nervous system. In
Brazil, there are currently several therapeutic options for the treatment of this condition, with …

[HTML][HTML] Confirmation of CD19+ B-Lymphocyte Depletion Prior to Intake of the Second Dose of Ocrelizumab in Multiple Sclerosis Patients

M Radmilo, S Pavelin, I Vujović, J Šoda… - Biomedicines, 2023 - mdpi.com
The aim of the retrospective study was to compare the immunophenotyping of T-
lymphocytes, B-lymphocytes, and natural killer cells before the administration of the first and …

Assessment of ocrelizumab impact on neurofilament levels in multiple sclerosis patients

S Maier, A Huțanu, L Bărcuțean… - Revista Romana de …, 2024 - sciendo.com
Background Multiple sclerosis (MS) is a debilitating neurological disease characterized by
inflammation, demyelination, and neurodegeneration in the central nervous system. Despite …