The syncytium of cardiomyocytes in the heart is tethered within a matrix composed
principally of type I fibrillar collagen. The matrix has diverse mechanical functions that …

Half of patients with heart failure (HF) have a preserved left ventricular ejection fraction
(HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF …

Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

Heart failure (HF) is a complex syndrome that affects approximately 6.5 million adults in the
United States. About half of the 6.5 million adults with HF are estimated to be individuals with …

Quantitative-diffusion-tensor MRI consists of deriving and displaying parameters that
resemble histological or physiological stains, ie, that characterize intrinsic features of tissue …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

resultant striking increase in morbidity and mortality. The transition to symptomatic heart
failure is accompanied by further activation of neurohormonal and cytokine systems, as well …

The renin–angiotensin system (RAS) and transforming growth factor-β1 (TGF-β1) play a
pivotal role in the development of cardiac hypertrophy and heart failure. Recent studies …

Background—Excessive myocardial fibrosis impairs cardiac function in hypertensive hearts.
Roles of transforming growth factor (TGF)-β in myocardial remodeling and cardiac …

The potent mineralocorticoid aldosterone has a multifaceted role in the pathogenesis of
congestive heart failure. In addition to its contribution to salt and water retention, it also …