Emotions arise from activations of specialized neuronal populations in several parts of the
cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and …

This review assesses the abuse potential of medically-administered psilocybin, following the
structure of the 8 factors of the US Controlled Substances Act (CSA). Research suggests the …

Neuroplasticity can be defined as the ability of the nervous system to respond to intrinsic or
extrinsic stimuli by reorganizing its structure, function and connections. Major advances in …

Drug addiction is a chronically relapsing disorder that has been characterized by (1)
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence …

Summary Since 1997 the US National Institute on Drug Abuse has advocated a brain
disease model of addiction (BDMA). We assess the strength of evidence for the BDMA in …

Investigations of long-term changes in brain structure and function that accompany chronic
exposure to drugs of abuse suggest that alterations in gene regulation contribute …

What we eat, when and how much, all are influenced by brain reward mechanisms that
generate “liking” and “wanting” for foods. As a corollary, dysfunction in reward circuits might …

We present a brief overview of the incentive sensitization theory of addiction. This posits that
addiction is caused primarily by drug-induced sensitization in the brain mesocorticolimbic …

What brain reward systems mediate motivational 'wanting'and hedonic 'liking'for food
rewards? And what roles do those systems play in eating disorders? This article surveys …

Introduction Debate continues over the precise causal contribution made by mesolimbic
dopamine systems to reward. There are three competing explanatory categories:'liking' …