The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in
motivated behaviors, various types of reward, and, more recently, in cognitive processes …

Background: Alcohol use disorder (AUD) is a common and disabling mental disorder
associated with a significant burden of medical consequences and high socioeconomic …

Despite the generally held view that alcohol is an unspecific pharmacological agent, recent
molecular pharmacology studies demonstrated that alcohol has only a few known primary …

The obesity epidemic has been widely publicized in the media worldwide. Investigators at all
levels have been looking for factors that have contributed to the development of this …

Dysregulation of the brain emotional systems that mediate arousal and stress is a key
component of the pathophysiology of drug addiction. Drug addiction is a chronically …

Substance and alcohol use disorders impose large health and economic burdens on
individuals, families, communities, and society. Neither prevention nor treatment efforts are …

Studies using animal models of adolescent exposure to alcohol, nicotine, cannabinoids, and
the stimulants cocaine, 3, 4-methylenedioxymethampethamine and methamphetamine have …

Evidence that psychoactive substance use disorders, bulimia nervosa, pathological
gambling, and sexual addiction share an underlying biopsychological process is …

In this review we discuss the evidence that drug addiction, defined as a maladaptive
compulsive habit, results from the progressive subversion by addictive drugs of striatum …

Drug addiction presents as a chronic relapsing disorder characterized by persistent drug‐
seeking and drug‐taking behaviours. Given the significant detrimental effects of this disease …