Tissue injury triggers a complex series of cellular responses, starting from inflammation
activated by tissue and cell damage and proceeding to healing. By clearing cell debris …

Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a
wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are …

Skeletal muscle fibers express distinct gene programs during development and maturation,
but the underlying gene regulatory networks that confer stage-specific myofiber properties …

One of the most fascinating questions in regenerative biology is why some animals can
regenerate injured structures while others cannot. Skeletal muscle has a remarkable …

Skeletal muscle injuries occur frequently in daily life and exercise. Understanding the
mechanisms of regeneration is critical for accelerating the repair and regeneration of …

MyoD, Myf5, myogenin, and MRF4 (also known as Myf6 or herculin) are myogenic
regulatory factors (MRFs). MRFs are regarded as master transcription factors that are …

Mef2 is a conserved and significant transcription factor in the control of muscle gene
expression. In cell culture Mef2 synergises with MyoD-family members in the activation of …

Intramuscular fat (IMF) content is a crucial determinant of meat quality traits in livestock. A
network of transcription factors act in concert to regulate adipocyte formation and …

Motivation Single-cell RNA-sequencing (scRNA-seq) offers unprecedented resolution for
studying cellular decision-making processes. Robust inference of cell state transition paths …

Cancer cachexia, and its associated complications, represent a large and currently
untreatable roadblock to effective cancer management. Many potential therapies have been …