The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease
G Burgstaller, B Oehrle, M Gerckens… - European …, 2017 - Eur Respiratory Soc
The pulmonary extracellular matrix (ECM) determines the tissue architecture of the lung, and
provides mechanical stability and elastic recoil, which are essential for physiological lung …
provides mechanical stability and elastic recoil, which are essential for physiological lung …
Microbiome effects on immunity, health and disease in the lung
Chronic respiratory diseases, including asthma, chronic obstructive pulmonary disease
(COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity …
(COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity …
[HTML][HTML] Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis
Cancer cell genetic variability and similarity to host cells have stymied development of broad
anti-cancer therapeutics. Our innate immune system evolved to clear genetically diverse …
anti-cancer therapeutics. Our innate immune system evolved to clear genetically diverse …
Necroptosis signaling promotes inflammation, airway remodeling, and emphysema in chronic obstructive pulmonary disease
Z Lu, HP Van Eeckhoutte, G Liu, PM Nair… - American journal of …, 2021 - atsjournals.org
Rationale: Necroptosis, mediated by RIPK3 (receptor-interacting protein kinase 3) and
MLKL (mixed lineage kinase domain-like), is a form of regulated necrosis that can drive …
MLKL (mixed lineage kinase domain-like), is a form of regulated necrosis that can drive …
A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis
Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and
death worldwide. Inhalation of cigarette smoke (CS) is the major cause in developed …
death worldwide. Inhalation of cigarette smoke (CS) is the major cause in developed …
Extracellular matrix component remodeling in respiratory diseases: what has been found in clinical and experimental studies?
Changes in extracellular matrix (ECM) components in the lungs are associated with the
progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease …
progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease …
Porcine models of cutaneous wound healing
M Seaton, A Hocking, NS Gibran - ILAR journal, 2015 - academic.oup.com
Cutaneous wound healing in the pig is frequently used as a model for human cutaneous
wound healing. In this review, we examine the appropriateness of this model for studying …
wound healing. In this review, we examine the appropriateness of this model for studying …
The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD
JM Leung, PY Tiew, M Mac Aogáin, KF Budden… - …, 2017 - Wiley Online Library
ABSTRACT COPD is a major global concern, increasingly so in the context of ageing
populations. The role of infections in disease pathogenesis and progression is known to be …
populations. The role of infections in disease pathogenesis and progression is known to be …
Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD)
We explore potential dysregulation of macrophage phenotypes in COPD pathogenesis
through integrated study of human small airway tissue, bronchoalveolar lavage (BAL) and …
through integrated study of human small airway tissue, bronchoalveolar lavage (BAL) and …
Chronic exposure to electronic cigarettes results in impaired cardiovascular function in mice
IM Olfert, E DeVallance, H Hoskinson… - Journal of applied …, 2018 - journals.physiology.org
Proponents for electronic cigarettes (E-cigs) claim that they are a safe alternative to tobacco-
based cigarettes; however, little is known about the long-term effects of exposure to E-cig …
based cigarettes; however, little is known about the long-term effects of exposure to E-cig …