Aging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and
immune systems), which preserve the organism's health. We propose that the age-related …

Sexual dimorphism is a key factor to consider in the ageing process given the impact that it
has on life expectancy. The oxidative-inflammatory theory of ageing states that the ageing …

Fragments of mitochondrial DNA (mtDNA) are released outside the cell and they appear to
persist in extracellular fluids as circulating, cell-free, mtDNA (ccf-mtDNA). When compared to …

Mitochondria play a key role in the pathophysiology of post-injury inflammation. Cell-free
mitochondrial DNA (cf-mtDNA) is now understood to catalyse sterile inflammation after …

Simple Summary The aim of this review is to evaluate the present status of the use of cell-
free DNA and its fraction of circulating tumor DNA (ctDNA) because this year July 2022, an …

During tissue injury events, the innate immune system responds immediately to alarms sent
from the injured cells, and the adaptive immune system subsequently joins in the …

Schizophrenia is associated with low-grade systemic inflammation. Circulating cell-free DNA
(c-cfDNA) belongs to the DAMP class. The major research question was: can the c-cfDNA of …

As peripheral blood contains fluctuated levels of circulating cell-free mitochondrial DNA (ccf
mtDNA), we aimed to evaluate ccf mtDNA as a biomarker for diagnosis and prognosis of …

Purpose Cancer-related fatigue (CRF) and chemotherapy-related cognitive impairment
(CRCI) are reported to be associated with mitochondrial dysfunction. Hence, mitochondrial …

There is currently no proposed stroke biomarker with consistent application in clinical
practice. A number of studies have examined cell-free DNA (cfDNA), which circulates in …