Oxidative stress is a key cause of ischemic stroke and an initiator of neuronal dysfunction
and death, mainly through the overproduction of peroxides and the depletion of antioxidants …

Over the past five decades, thanatology has come to include the study of how individual
cells in our bodies die appropriately and inappropriately in response to physiological and …

In addition to the deregulation of gene transcriptions and post-translational protein
modifications, the aberrant translation from mRNAs to proteins plays an important role in the …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …

COVID-19 has spread globally to over 200 countries with more than 40 million confirmed
cases and one million deaths as of November 1, 2020. The SARS-CoV-2 virus, leading to …

The integrated stress response (ISR) triggered in response to various cellular stress enables
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …

Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs
through over-stimulation of glutamate receptors, specifically NMDAR, while in the non …

To maintain proteostasis, cells must integrate information and activities that supervise
protein synthesis, protein folding, conformational stability, and also protein degradation …

The integrated stress response (ISR) is a highly conserved biochemical pathway involved in
maintaining proteostasis and cell health in the face of diverse stressors. In this Review, we …