TBX1 functions as a tumor suppressor in thyroid cancer through inhibiting the activities of the PI3K/AKT and MAPK/ERK pathways

N Wang, Y Li, J Wei, J Pu, R Liu, Q Yang, H Guan… - Thyroid, 2019 - liebertpub.com
Background: TBX1 is a member of the T-box family of transcription factors characterized by a
conserved DNA binding domain termed T-box. TBX1 has been reported to be …

Long non-coding RNAs in thyroid cancer: Biological functions and clinical significance

F Sui, M Ji, P Hou - Molecular and Cellular Endocrinology, 2018 - Elsevier
Thyroid cancer is the most common endocrine malignant tumor with rapidly increasing
incidence in recent decades. Although the majority of thyroid cancers are relatively indolent …

Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression

H Wei, L Pan, D Tao, R Li - Biochemical and biophysical research …, 2018 - Elsevier
In recent years, more and more circular RNAs (circRNAs) have been identified in multiple
tissues and cells. Increasing evidences show circRNAs play important roles in human …

ZNF677 suppresses Akt phosphorylation and tumorigenesis in thyroid cancer

Y Li, Q Yang, H Guan, B Shi, M Ji, P Hou - Cancer research, 2018 - AACR
The zinc finger protein 677 (ZNF677) belongs to the zinc finger protein family, which
possesses transcription factor activity by binding sequence-specific DNA. Previous studies …

SIRT7 promotes thyroid tumorigenesis through phosphorylation and activation of Akt and p70S6K1 via DBC1/SIRT1 axis

H Li, Z Tian, Y Qu, Q Yang, H Guan, B Shi, M Ji, P Hou - Oncogene, 2019 - nature.com
SIRT7 is an NAD+-dependent histone/non-histone deacetylase, which is highly expressed
in different types of cancer including thyroid cancer; however, its biological function in …

[HTML][HTML] Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors

VGA Arciuch, MA Russo, M Dima, KS Kang, F Dasrath… - Oncotarget, 2011 - ncbi.nlm.nih.gov
Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer, and often
derives from pre-existing well-differentiated tumors. Despite a relatively low prevalence, it …

[PDF][PDF] The expression and function of long noncoding RNA lncRNA-ATB in papillary thyroid cancer.

XM Fu, W Guo, N Li, HZ Liu, J Liu… - European Review for …, 2017 - europeanreview.org
lncRNA-ATB expression and function in PTC Page 1 3239 CONCLUSIONS: LncRNA-ATB is
upregulated and functions as an oncogene in PTC. Furthermore, lncRNA-ATB may serve as a …

Genetic profile of advanced thyroid cancers in relation to distant metastasis

E Song, DE Song, J Ahn, TY Kim… - Endocrine-related …, 2020 - erc.bioscientifica.com
Major clinical challenges exist with differentiated thyroid cancers with distant metastases or
rare but aggressive types, such as poorly differentiated thyroid carcinomas and anaplastic …

[HTML][HTML] lncRNA LINC00673 induces proliferation, metastasis and epithelial-mesenchymal transition in thyroid carcinoma via Kruppel-like factor 2

E Xia, A Bhandari, Y Shen… - … Journal of Oncology, 2018 - spandidos-publications.com
The incidence of thyroid cancer has increased in the past decades; however, the underlying
molecular mechanisms of thyroid cancer tumorigenesis remain unknown. Using sequencing …

[HTML][HTML] N-cadherin promotes thyroid tumorigenesis through modulating major signaling pathways

C Da, K Wu, C Yue, P Bai, R Wang, G Wang, M Zhao… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Epithelial-mesenchymal transition (EMT), a crucial step in disease progression,
plays a key role in tumor metastasis. N-cadherin, a well-known EMT marker, acts as a major …