The neuropeptide substance P (SP) triggers a variety of tumor‐promoting signaling
pathways through the activation of neurokinin‐1receptor (NK1R), a class of neurokinin G …

Introduction Antineoplastic drugs may induce several side effects, including chemotherapy-
induced nausea and vomiting (CINV). Two neurotransmitters play a central role in mediating …

Breast cancer (BC) is considered the leading cause of mortality and morbidity among adult
women worldwide, and it is associated with many genetic or hormonal factors. Despite the …

Background Results from a phase III, randomized, double-blind, active comparator-
controlled, parallel-group trial evaluating fosaprepitant for the prevention of chemotherapy …

Ifosfamide is one of the chemotherapy regimens which potentially causes neurotoxicity in
patients up to 30%. Aprepitant is administered as an anti-emetic agent in chemotherapy and …

Objective: The purpose of this study was to investigate the efficacy and safety of netupitant/
palonosetron (NEPA) for the prevention of chemotherapy-induced nausea and vomiting …

Nausea and vomiting are often considered as stressful symptoms of many diseases and
drugs. In fact they are the most feared and debilitating side-effects of many cancer …

This 2‐part study evaluated the QT/QTc prolongation potential and safety and
pharmacokinetics of the antiemetic rolapitant, a neurokinin‐1 receptor antagonist. Part 1 was …

Background: Results from a phase III, randomized, double-blind, active comparator-
controlled, parallel-group trial evaluating fosaprepitant for the prevention of chemotherapy …

Although vasomotor symptoms (VMS) are a ubiqui-tous problem for perimenopausal and
postmenopausal women, 1-3 effective and well-tolerated treatment options are somewhat …