Gallic acid (GA), also known as 3, 4, 5-trihydroxybenzoic acid, is a natural secondary
metabolite and widely isolated from various fruits, plants and nuts. In recent years, GA has …

Cancer is one of the leading causes of death worldwide. Chemotherapy and radiotherapy
are the conventional primary treatments for cancer patients. However, most of cancer cells …

Morroniside, a major iridoid glycoside isolated from Cornus officinalis, has a variety of
beneficial pharmacological properties. Although morroniside has recently been reported to …

The clinical application of immunotherapy is the milestone of cancer treatment. However,
some patients have bad reaction. Cyclooxygenase-2 (COX-2) is frequently expressed in …

Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors
(COXibs) inhibit the progression of endometrial cancer, ovarian cancer and cervical cancer …

Based on the core structure of diflunisal drug, herein, we report a resembling series of biaryl
analogs (3a–j) containing halogens, nitro, and methoxy substituents. They were designed …

The skin is directly exposed to the polluted atmospheric environment, and skin diseases,
such as atopic dermatitis and acne vulgaris, can be induced or exacerbated by airborne …

Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of
physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most …

Bioactive lipid mediators play a major role in regulating inflammatory processes. Herein,
early pro-inflammatory phases are characterized and regulated by prostanoids and …

Oxidative stress is a common physiopathological condition enrolled in risk factors for
cardiovascular diseases. Individuals in such a redox imbalance status present endothelial …