Pharmacogenomics: driving personalized medicine
Personalized medicine tailors therapies, disease prevention, and health maintenance to the
individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent …
individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent …
[HTML][HTML] The NIH Comparative Genomics Resource: addressing the promises and challenges of comparative genomics on human health
K Bornstein, G Gryan, ES Chang, A Marchler-Bauer… - BMC genomics, 2023 - Springer
Comparative genomics is the comparison of genetic information within and across
organisms to understand the evolution, structure, and function of genes, proteins, and non …
organisms to understand the evolution, structure, and function of genes, proteins, and non …
[HTML][HTML] RESCRIPt: Reproducible sequence taxonomy reference database management
Nucleotide sequence and taxonomy reference databases are critical resources for
widespread applications including marker-gene and metagenome sequencing for …
widespread applications including marker-gene and metagenome sequencing for …
[HTML][HTML] Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring
Tumor microbiota can produce active metabolites that affect cancer and immune cell
signaling, metabolism, and proliferation. Here, we explore tumor and gut microbiome …
signaling, metabolism, and proliferation. Here, we explore tumor and gut microbiome …
[HTML][HTML] Rapid and sensitive detection of genome contamination at scale with FCS-GX
A Astashyn, ES Tvedte, D Sweeney, V Sapojnikov… - Genome biology, 2024 - Springer
Assembled genome sequences are being generated at an exponential rate. Here we
present FCS-GX, part of NCBI's Foreign Contamination Screen (FCS) tool suite, optimized to …
present FCS-GX, part of NCBI's Foreign Contamination Screen (FCS) tool suite, optimized to …
Large language models in biomedical natural language processing: benchmarks, baselines, and recommendations
Biomedical literature is growing rapidly, making it challenging to curate and extract
knowledge manually. Biomedical natural language processing (BioNLP) techniques that …
knowledge manually. Biomedical natural language processing (BioNLP) techniques that …
[HTML][HTML] m7GHub V2.0: an updated database for decoding the N7-methylguanosine (m7G) epitranscriptome
With recent progress in mapping N7-methylguanosine (m7G) RNA methylation sites, tens of
thousands of experimentally validated m7G sites have been discovered in various species …
thousands of experimentally validated m7G sites have been discovered in various species …
[HTML][HTML] An archaeal lid-containing feruloyl esterase degrades polyethylene terephthalate
P Perez-Garcia, J Chow, E Costanzi… - Communications …, 2023 - nature.com
Polyethylene terephthalate (PET) is a commodity polymer known to globally contaminate
marine and terrestrial environments. Today, around 80 bacterial and fungal PET-active …
marine and terrestrial environments. Today, around 80 bacterial and fungal PET-active …
[HTML][HTML] P450Rdb: A manually curated database of reactions catalyzed by cytochrome P450 enzymes
Abstract Introduction Cytochrome P450 enzymes (P450s) are recognized as the most
versatile catalysts worldwide, playing vital roles in numerous biological metabolism and …
versatile catalysts worldwide, playing vital roles in numerous biological metabolism and …
[HTML][HTML] Functional filter for whole-genome sequencing data identifies HHT and stress-associated non-coding SMAD4 polyadenylation site variants> 5 kb from coding …
S Xiao, Z Kai, D Murphy, D Li, D Patel… - The American Journal of …, 2023 - cell.com
Despite whole-genome sequencing (WGS), many cases of single-gene disorders remain
unsolved, impeding diagnosis and preventative care for people whose disease-causing …
unsolved, impeding diagnosis and preventative care for people whose disease-causing …