Measurement of endogenous versus exogenous formaldehyde–induced DNA–protein crosslinks in animal tissues by stable isotope labeling and ultrasensitive mass …

Y Lai, R Yu, HJ Hartwell, BC Moeller, WM Bodnar… - Cancer research, 2016 - AACR
DNA–protein crosslinks (DPC) arise from a wide range of endogenous and exogenous
chemicals, such as chemotherapeutic drugs and formaldehyde. Importantly, recent …

Holding all the cards—how fanconi anemia proteins deal with replication stress and preserve genomic stability

A Datta, RM Brosh Jr - Genes, 2019 - mdpi.com
Fanconi anemia (FA) is a hereditary chromosomal instability disorder often displaying
congenital abnormalities and characterized by a predisposition to progressive bone marrow …

Photoresponsive micelles enabling codelivery of nitric oxide and formaldehyde for combinatorial antibacterial applications

Y Duan, K He, G Zhang, J Hu - Biomacromolecules, 2021 - ACS Publications
It is of particular interest to develop new antibacterial agents with low risk of drug resistance
development and low toxicity toward mammalian cells to combat pathogen infections …

TP-FRET-based fluorescent sensor for ratiometric detection of formaldehyde in real food samples, living cells, tissues, and zebrafish

H Ding, G Yuan, L Peng, L Zhou… - Journal of agricultural and …, 2020 - ACS Publications
Formaldehyde (FA, HCHO) is a highly reactive carbonyl species, which is very harmful to
humans and the environment as a tissue fixative and preservative. Therefore, developing …

Remodeling of interstrand crosslink proximal replisomes is dependent on ATR, FANCM, and FANCD2

J Huang, J Zhang, MA Bellani, D Pokharel, J Gichimu… - Cell reports, 2019 - cell.com
Eukaryotic replisomes are driven by the mini chromosome maintenance (MCM [M]) helicase
complex, an offset ring locked around the template for leading strand synthesis by CDC45 …

When genome maintenance goes badly awry

EM Kass, ME Moynahan, M Jasin - Molecular cell, 2016 - cell.com
Genetic abnormalities are present in all tumor types, although the frequency and type can
vary. Chromosome abnormalities include highly aberrant structures, particularly …

Overcoming drug resistance in advanced prostate cancer by drug repurposing

HF Bahmad, T Demus, MM Moubarak, D Daher… - Medical …, 2022 - mdpi.com
Prostate cancer (PCa) is the second most common cancer in men. Common treatments
include active surveillance, surgery, or radiation. Androgen deprivation therapy and …

Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice

QS Zhang, W Tang, M Deater, N Phan… - Blood, The Journal …, 2016 - ashpublications.org
Fanconi anemia (FA) is an inherited bone marrow failure disorder associated with a high
incidence of leukemia and solid tumors. Bone marrow transplantation is currently the only …

Semicarbazide-based fluorescent probe for detection of Cu2+ and formaldehyde in different channels

Y He, H Wang, X Fang, W Zhang, J Zhang… - Spectrochimica Acta Part …, 2023 - Elsevier
Two fluorescent sensors with the receptor semicarbazide respectively at 7-(CAA) and 3-
position (CAB) of coumarin were designed and synthesized. CAA exhibits fluorescence turn …

Hemin loaded Zn− N–C single-atom nanozymes for assay of propyl gallate and formaldehyde in food samples

H Li, Q Li, Q Shi, Y Wang, X Liu, H Tian, X Wang… - Food Chemistry, 2022 - Elsevier
Single-atom nanozymes (SAzymes) show distinct advantages in catalytic activity and
selectivity owing to their stability and special characteristic of maximum atomic utilization …