Cancer is one of the most serious public health issues worldwide, demanding ongoing
efforts to find novel therapeutic agents and approaches. Amid growing interest in the …

Sirtuins (SIRTs) represent a class of nicotinamide adenine dinucleotide (NAD+)-dependent
protein deacetylases that exert a crucial role in cellular signal transduction and various …

Therapeutically targeting senescent cells seems to be an interesting perspective in treating
chronic lung diseases, which are often associated with human aging. The combination of the …

Breast cancer (BC) is currently one of the most common cancers in women worldwide with a
rising tendency. Epigenetics, generally inherited variations in gene expression that occur …

Purpose Heterocyclic compounds are organic compounds with heterocyclic structures,
which are common in drug molecules. They include pyrazines with diverse functions …

Introduction Osteoarthritis (OA) is associated with excessive cartilage degradation,
inflammation, and decreased autophagy. Insufficient efficacy of conventional monotherapies …

Resveratrol is a plant-derived polyphenol known for its anti-inflammatory and anti-tumor
properties in laboratory models and living organisms. Recent studies suggest that certain …

Background Colorectal cancer (CRC), which is mainly caused by epigenetic and lifestyle
factors, is very often associated with functional plasticity during its development. In addition …

Among functional imaging methods, metabolic connectivity (MC) is increasingly used for
investigation of regional network changes to examine the pathophysiology of …

Resveratrol is a polyphenol present in various plant sources. Studies have reported
numerous potential health benefits of resveratrol, exhibiting anti-aging, anti-inflammatory …