Acute spinal cord injury: A review of pathophysiology and potential of non-steroidal anti-inflammatory drugs for pharmacological intervention

E Hayta, H Elden - Journal of Chemical Neuroanatomy, 2018 - Elsevier
Acute spinal cord injury (SCI) is one of the serious central nervous system injuries, which
can lead to significant neurological impairments and a reduction in quality of life with loss in …

Ibuprofen-based advanced therapeutics: Breaking the inflammatory link in cancer, neurodegeneration, and diseases

A Upadhyay, A Amanullah, V Joshi… - Drug metabolism …, 2021 - Taylor & Francis
Ibuprofen is a classical nonsteroidal anti-inflammatory drug (NSAID) highly prescribed to
reduce acute pain and inflammation under an array of conditions, including rheumatoid …

Stigmasterol regulates microglial M1/M2 polarization via the TLR4/NF‐κB pathway to alleviate neuropathic pain

W Si, X Li, B Jing, S Chang, Y Zheng… - Phytotherapy …, 2024 - Wiley Online Library
Abstract (Switching from the microglial M1 phenotype to the M2 phenotype is a promising
therapeutic strategy for neuropathic pain (NP). This study aimed to investigate the potential …

[HTML][HTML] On the therapeutic targets and pharmacological treatments for pain relief following spinal cord injury: A mechanistic review

S Fakhri, F Abbaszadeh, M Jorjani - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders,
which interferes with daily activities and life of the affected patients. Despite many …

Targeting the blood-spinal cord barrier: a therapeutic approach to spinal cord protection against ischemia-reperfusion injury

J Hu, Q Yu, L Xie, H Zhu - Life sciences, 2016 - Elsevier
One of the principal functions of physical barriers between the blood and central nervous
system protects system (ie, blood brain barrier and blood-spinal cord barrier) is the …

Systemic administration of allogeneic cord blood mononuclear cells in adults with severe acute contusion spinal cord injury: phase 1/2a pilot clinical study–safety and …

VA Smirnov, SM Radaev, YV Morozova, SI Ryabov… - World Neurosurgery, 2022 - Elsevier
Objective Phase 1 of the SUBSCI I/IIa (Systemic Umbilical Cord Blood Administration in
Patients with Acute Severe Contusion Spinal Cord Injury) study focused on safety and …

Improved functional recovery in rat spinal cord injury induced by a drug combination administered with an implantable polymeric delivery system

A Bighinati, ML Focarete, C Gualandi… - Journal of …, 2020 - liebertpub.com
Spinal cord injury (SCI) is an incurable condition, in which a cascade of cellular and
molecular events triggered by inflammation and excitotoxicity impairs endogenous …

Nonsteroidal anti-inflammatory drugs and their neuroprotective role after an acute spinal cord injury: a systematic review of animal models

MJ Lambrechts, JL Cook - Global spine journal, 2021 - journals.sagepub.com
Study Design: Systematic review. Objective: Spinal cord injuries (SCIs) resulting in motor
deficits can be devastating injuries resulting in millions of health care dollars spent per …

Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy

A Micov, M Tomić, U Pecikoza, N Ugrešić… - Pharmacological …, 2015 - Elsevier
Painful diabetic neuropathy is difficult to treat. Single analgesics often have insufficient
efficacy and poor tolerability. Combination therapy may therefore be of particular benefit …

Small molecules: therapeutic application in neuropsychiatric and neurodegenerative disorders

S Schiavone, L Trabace - Molecules, 2018 - mdpi.com
In recent years, an increasing number of studies have been published, focusing on the
potential therapeutic use of small catalytic agents with strong biological properties. So far …