Despite an estimated heritability of~ 50%, genome-wide association studies of opioid use
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross …

Abstract Purpose of Review Opioid receptors are widely expressed in the human brain. A
number of features commonly associated with drug use disorder, such as difficulties in …

Opioid-induced microglia reactivity affects opioid reward and analgesic processes in ways
that may contribute to the neurocognitive impairment observed in opioid addicted …

Background and aims Individuals with heroin addiction are prone to dysfunctional decision-
making. They frequently choose the short-term rewarding option of drug intake despite …

Evidence of central nervous system (CNS) exogenous opioid effects in humans has been
primarily gained through neuroimaging of three participant populations: individuals after …

Despite an estimated twin heritability of∼ 50%, genome-wide association studies (GWAS) of
opioid use disorder (OUD) have revealed few genome-wide significant (GWS) loci, with …

Objective Evidence suggests that blunted reward responsiveness may account for poor
clinical outcomes in both opioid use disorder (OUD) and chronic pain. Understanding how …

Cannabis and opioid co-dependence is independently associated with cognitive
impairments. We examined neurocognitive dysfunctions in people with concurrent opioid …

The substantial personal, societal, and economic impacts of opioid addiction drive research
investigating how opioid addiction affects the brain, and whether therapies attenuate …

Problematic opioid use that emerges in a subset of individuals may be due to pre-existing
disruptions in the biobehavioral mechanisms that regulate drug use. The identity of these …