Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays vital
roles in modulating metabolism, immunity, and oncogenesis. ATF3 acts as a hub of the …

Background Aspirin has been associated with a reduced risk of colorectal cancer, and
possibly of a few other digestive tract cancers. The quantification of risk reduction and the …

Oxidative damage and inflammation have been pointed out in preclinical studies as the root
cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer's …

Many cancer immunotherapies developed in experimental animals have been tested in
clinical trials. Although some have shown modest clinical effects, most have not been …

Curcumin is a polyphenol derived from the herbal remedy and dietary spice turmeric. It
possesses diverse anti-inflammatory and anti-cancer properties following oral or topical …

Gallic acid, a predominant polyphenol, has been shown to inhibit carcinogenesis in animal
models and in vitro cancerous cell lines. The inhibitory effect of gallic acid on cancer cell …

Nonsteroidal anti-inflammatory drugs (NSAIDs) represent one of the most highly utilized
classes of pharmaceutical agents in medicine. All NSAIDs act through inhibiting …

Background Patients with familial adenomatous polyposis have a nearly 100 percent risk of
colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal …

Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-
inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 …

Curcuma spp. extracts, particularly the dietary polyphenol curcumin, prevent colon cancer in
rodents. In view of the sparse information on the pharmacodynamics and pharmacokinetics …