Parkinson's disease (PD) is a highly heterogeneous disorder, which probably consists of
multiple subtypes. Aggregation of misfolded alpha-synuclein and propagation of these …

Parkinson's disease (PD) is a neurodegenerative disease with a 200 year-long research
history. Our understanding about its clinical phenotype and pathogenesis remains limited …

Braak's hypothesis has been extremely influential over the last two decades. However,
neuropathological and clinical evidence suggest that the model does not conform to all …

Objective To date, 3 rare missense mutations in the SNCA (α‐synuclein) gene and the more
frequent duplications or triplications of the wild‐type gene are known to cause a broad array …

Parkinson's disease is the second most common neurodegenerative disorder. Although the
pathogenesis of Parkinson's disease is not entirely clear, the aberrant aggregation of α …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

The clinical diagnosis of Parkinson's disease rests on the identification of the characteristics
related to dopamine deficiency that are a consequence of degeneration of the substantia …

Aggregation of α‐synuclein, an abundant and conserved pre‐synaptic brain protein, is
implicated as a critical factor in several neurodegenerative diseases. These diseases …

Degeneration of the cardiac sympathetic nerve occurs in both Parkinson's disease (PD) and
dementia with Lewy bodies and begins early in the disease progression of PD, accounting …

Parkinson's disease (PD) is a slowly progressive movement disorder that results from the
loss of dopaminergic neurons in the substantia nigra, a small area of cells in the mid-brain …