Potassium-competitive acid blocker (P-CAB) is a class of drug that competitively blocks the
potassium-binding site of H+, K+-adenosine triphosphate (ATP) ase. Although the history of …

The upper esophageal sphincter (UES), consisting of the cricopharyngeus muscle among
others, remains tonically contracted to prevent air entry into the esophagus or reflux of …

Heartburn is a common symptom in clinical practice, but as many as 70% of patients have
normal findings from upper endoscopy. Most of these patients have nonerosive reflux …

Methods Patients with heartburn from the Beijing Anzhen Hospital, who underwent upper
gastrointestinal endoscopy and 24-hour MII/pH, were enrolled in this study. Results In all, 24 …

Abstract Purpose of Review This narrative review focuses on the presentation, contributing
factors, diagnosis, and treatment of non-acid reflux. We also propose algorithms for …

Functional esophageal disorders are characterized by typical esophageal symptoms that
are not explained by structural disorders, histopathology-based motor disturbances, or …

Introduction: Post-cholecystectomy syndrome and the concept of a causal relationship to
sphincter of Oddi dysfunction, despite the controversy, has presented a clinically relevant …

Typical reflux symptoms that respond well to proton pump inhibitor (PPI) therapy are key
factors predictive of an excellent outcome with antireflux surgery for gastroesophageal reflux …

Methods Impedance-pH monitoring tracings from 70 patients, 50 with non-erosive reflux
disease (NERD) and 20 with functional heartburn (FH), were reviewed. According to proton …

By means of 24 h multi-channel intraluminal impedance and pH recording (MII/pH), patients
with heartburn and normal upper gastrointestinal endoscopy findings can be classified into …