Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy
A paradigm shift has recently occurred in the field of cancer therapeutics. Traditional
anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting …
anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting …
Chemotherapy: a double-edged sword in cancer treatment
N Behranvand, F Nasri, R Zolfaghari Emameh… - Cancer immunology …, 2022 - Springer
Chemotherapy is a well-known and effective treatment for different cancers; unfortunately, it
has not been as efficient in the eradication of all cancer cells as been expected. The …
has not been as efficient in the eradication of all cancer cells as been expected. The …
M1/M2 macrophages and their overlaps–myth or reality?
Z Strizova, I Benesova, R Bartolini… - Clinical …, 2023 - portlandpress.com
Macrophages represent heterogeneous cell population with important roles in defence
mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations …
mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations …
Interleukin-1β and cancer
C Rébé, F Ghiringhelli - Cancers, 2020 - mdpi.com
Within a tumor, IL-1β is produced and secreted by various cell types, such as immune cells,
fibroblasts, or cancer cells. The IL1B gene is induced after “priming” of the cells and a …
fibroblasts, or cancer cells. The IL1B gene is induced after “priming” of the cells and a …
IL‐1 and IL‐1 regulatory pathways in cancer progression and therapy
A Mantovani, I Barajon, C Garlanda - Immunological reviews, 2018 - Wiley Online Library
Inflammation is an important component of the tumor microenvironment. IL‐1 is an
inflammatory cytokine which plays a key role in carcinogenesis and tumor progression. IL‐1 …
inflammatory cytokine which plays a key role in carcinogenesis and tumor progression. IL‐1 …
Proteolytic processing of interleukin-1 family cytokines: variations on a common theme
IS Afonina, C Müller, SJ Martin, R Beyaert - Immunity, 2015 - cell.com
Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and
IL-36, play a pivotal role in the initiation and amplification of immune responses. However …
IL-36, play a pivotal role in the initiation and amplification of immune responses. However …
Roles of IL-1 in cancer: from tumor progression to resistance to targeted therapies
V Gelfo, D Romaniello, M Mazzeschi, M Sgarzi… - International journal of …, 2020 - mdpi.com
IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-
inflammatory activity. Beyond its biological role as a regulator of the innate immune …
inflammatory activity. Beyond its biological role as a regulator of the innate immune …
IL-1 family cytokine regulation of vascular permeability and angiogenesis
E Fahey, SL Doyle - Frontiers in Immunology, 2019 - frontiersin.org
The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory
responses both in response to and acting as danger signals. It has long been established …
responses both in response to and acting as danger signals. It has long been established …
Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
Esophageal cancer (EC) is a disease often marked by aggressive growth and poor
prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant …
prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant …
Cytokines, IBD, and colitis-associated cancer
R Francescone, V Hou… - Inflammatory bowel …, 2015 - academic.oup.com
Inflammatory bowel diseases (IBDs) are debilitating conditions that result in intestinal
damage due to chronic inflammation. In addition, the perpetual state of inflammation …
damage due to chronic inflammation. In addition, the perpetual state of inflammation …