Ageing and chronic degenerative pathologies demonstrate the shared characteristics of
high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent …

Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …

Mesenchymal stem cells (MSCs) can be isolated from almost all tissues and effectively
expanded in vitro. Although their true in situ properties and biological functions remain to be …

Stem cell-based therapies for neurodegenerative diseases aim at halting clinical
deterioration by regeneration and by providing local support for damaged tissue …

Mesenchymal stromal cells are multipotent cells that are being used to treat a variety of
medical conditions. Over the past decade, there has been considerable excitement about …

Neurogenesis in the subgranular zone of the hippocampal dentate gyrus may act as an
endogenous repair mechanism in Alzheimer's disease (AD), and the Wnt signaling pathway …

Parkinson's disease (PD) is the second most common neurodegenerative disease
characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars …

Alzheimer's disease (AD) is the most common form of dementia. The risk of AD increases
with age. Although two of the main pathological features of AD, amyloid plaques and …

MicroRNAs (miRNAs) are potential therapeutic targets in a variety of pathological conditions
in the brain; however, their clinical application is hampered by lack of efficient delivery …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the
degeneration of dopaminergic neurons and/or loss od neuronal projections, in several …