Conspectus Protein post-translational modification (PTM) is a major mechanism for
functional diversification of the human genome and plays a crucial role in almost every …

Building on recent advances in peptide science, medicinal chemists have developed a
hybrid class of bioconjugates, called peptide–drug conjugates, that demonstrate improved …

Peptide-based drug development for CNS disorders is challenged by poor blood-brain
barrier (BBB) penetrability of peptides. While acylation protractions (lipidation) have been …

Polymeric prodrugs have been applied to control the delivery of various types of
therapeutics. Similarly, conjugation of peptide therapeutics to lipids has been used to …

Context Somapacitan is a long-acting GH derivative for treatment of GH deficiency (GHD).
Objective Evaluate the efficacy and tolerability of somapacitan in children with GHD after 2 …

The relay delivery strategy is a two-step targeting approach based on two distinct modules in
which the first step with an initiator is to artificially create a target/environment which can be …

Therapeutic protein, represented by antibodies, is of increasing interest in human medicine.
However, clinical translation of therapeutic protein is still largely hindered by different …

Delivery to peripheral lymphatics can be achieved following interstitial administration of
nano-sized delivery systems (nanoparticles, liposomes, dendrimers etc) or molecules that …

Since the first administration of insulin to a person with diabetes in 1922, scientific
contributions from academia and industry have improved insulin therapy and access. The …

Objectives Nanomedicines are being actively developed as inhalable drug delivery systems.
However, there is a distinct utility in developing smaller polymeric systems that can bind …