Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Background: Marfan syndrome (MFS) is an autosomal dominant disorder of the connective
tissue caused by mutations in the FBN1 (fibrillin-1) gene encoding a large glycoprotein in …

Abdominal aortic aneurysm (AAA) is one of the most dangerous cardiovascular diseases,
occurring mainly in men over the age of 55 years. As it is asymptomatic, patients are …

Background: Mural cells in ascending aortic aneurysms undergo phenotypic changes that
promote extracellular matrix destruction and structural weakening. To explore this biology …

The aging population is booming all over the world and arterial aging causes various age-
associated pathologies such as cardiovascular diseases (CVDs). The aorta is the largest …

The proteins and polysaccharides of the extracellular matrix (ECM) provide architectural
support as well as biochemical and biophysical instruction to cells. Decellularized, ECM …

Background Alterations in the anatomic and biomechanical properties of the ascending
aorta (AAo) can give rise to various vascular pathologies. The aim of the current study is to …

Background Abdominal aortic aneurysms (AAA) can lead to catastrophic events such as
dissection or rupture, and are an expression of general aortic disease. Low wall shear stress …

The developmental origin, anatomical location, and other factors contribute to aortic
heterogeneity in a physiological state. On this basis, vascular diseases occur at different …